Prevalence of peripheral neuropathy in pre-diabetes: a systematic review.
Prevalence of peripheral neuropathy in pre-diabetes: a systematic review.
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DOI：
10.1136/bmjdrc-2020-002040
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发表时间：
2021-05
影响因子：
4.1
通讯作者：
Alam U
中科院分区：
文献类型：
--
作者：
Kirthi V;Perumbalath A;Brown E;Nevitt S;Petropoulos IN;Burgess J;Roylance R;Cuthbertson DJ;Jackson TL;Malik RA;Alam U
有越来越多的证据表明，糖尿病前期的周围神经病变过多。我们的目的是确定其患病率，包括诊断方法对患病率的影响，通过系统评价，根据系统评价和荟萃分析指南的首选报告项目进行系统评价。在MEDLINE、EMBASE、PubMed、Web of Science和科克伦对照试验中心注册库中进行了全面的电子文献检索，检索时间为从开始到2020年6月1日。两名评审员独立选择研究，提取数据并评估偏倚风险。通过神经病变评估方法进行评价。在筛选了1784篇摘要并审查了84篇全文记录后，纳入了29项研究（9351名参与者）。患病率估计值范围广泛（2%-77%，IQR：6%-34%），但大多数研究（n=21，72%）报告的患病率≥ 10%。使用足底温度描记法、多模式定量感觉测试和神经传导测试报告了三种最高患病率估计值，分别为77%（95% CI：54%至100%）、71%（95% CI：55%至88%）和66%（95% CI：53%至78%）。一般而言，评价小神经纤维参数的研究得出周围神经病变的患病率较高。由于各种研究人群和评估神经病变的方法，患病率估计值存在明显的异质性。大多数研究报告称，糖尿病前期周围神经病变的患病率高于背景人群的预期，主要是小神经纤维起源。鉴于糖尿病前期的显著上升，需要进一步考虑在这一人群中进行靶向筛查。开发风险分层工具可能有助于早期干预。
There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to determine its prevalence, including the impact of diagnostic methodology on prevalence rates, through a systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive electronic bibliographic search was performed in MEDLINE, EMBASE, PubMed, Web of Science and the Cochrane Central Register of Controlled Trials from inception to June 1, 2020. Two reviewers independently selected studies, extracted data and assessed risk of bias. An evaluation was undertaken by method of neuropathy assessment. After screening 1784 abstracts and reviewing 84 full-text records, 29 studies (9351 participants) were included. There was a wide range of prevalence estimates (2%–77%, IQR: 6%–34%), but the majority of studies (n=21, 72%) reported a prevalence ≥10%. The three highest prevalence estimates of 77% (95% CI: 54% to 100%), 71% (95% CI: 55% to 88%) and 66% (95% CI: 53% to 78%) were reported using plantar thermography, multimodal quantitative sensory testing and nerve conduction tests, respectively. In general, studies evaluating small nerve fiber parameters yielded a higher prevalence of peripheral neuropathy. Due to a variety of study populations and methods of assessing neuropathy, there was marked heterogeneity in the prevalence estimates. Most studies reported a higher prevalence of peripheral neuropathy in pre-diabetes, primarily of a small nerve fiber origin, than would be expected in the background population. Given the marked rise in pre-diabetes, further consideration of targeting screening in this population is required. Development of risk-stratification tools may facilitate earlier interventions.
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影响因子：
3.7
作者：
Hovaguimian, Alexandra;Gibbons, Christopher H.
通讯作者：
Gibbons, Christopher H.
影响因子：
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作者：
FRANKLIN, GM;KAHN, LB;HAMMAN, RF
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HAMMAN, RF
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作者：
Bach, D;Naon, D;Zorzano, A
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Zorzano, A
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作者：
Callaghan BC;Gao L;Li Y;Zhou X;Reynolds E;Banerjee M;Pop-Busui R;Feldman EL;Ji L
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Ji L
影响因子：
13.6
作者：
Hanewinckel R;van Oijen M;Ikram MA;van Doorn PA
通讯作者：
van Doorn PA