Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
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DOI：
10.1016/j.neuron.2008.12.021
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发表时间：
2009-02-26
期刊：
影响因子：
16.2
通讯作者：
Jan, Yuh-Nung
中科院分区：
文献类型：
--
作者：
Yang, Chung-hui;Rumpf, Sebastian;Xiang, Yang;Gordon, Michael D.;Song, Wei;Jan, Lily Y.;Jan, Yuh-Nung
Mating induces changes in the receptivity and egg-laying behavior in Drosophila females, primarily due to a peptide pheromone called sex peptide which is transferred with the sperm into the female reproductive tract during copulation. Whereas sex peptide is generally believed to modulate fruitless-GAL4-expressing neurons in the central nervous system to produce behavioral changes, we found that six to eight sensory neurons on the reproductive tract labeled by both ppk-GAL4 and fruitless-GAL4 can sense sex peptide to control the induction of postmating behaviors. In these sensory neurons, sex peptide appears to act through Pertussis toxin-sensitive G proteins and suppression of protein kinase A activity to reduce synaptic output. Our results uncover a neuronal mechanism by which sex peptide exerts its control over reproductive behaviors in Drosophila females.
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