Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.
Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.
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DOI：
10.1002/brb3.1766
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发表时间：
2020-09
影响因子：
3.1
通讯作者：
Lazar SW
中科院分区：
文献类型：
--
作者：
Sevinc G;Greenberg J;Hölzel BK;Gard T;Calahan T;Brunsch V;Hashmi JA;Vangel M;Orr SP;Milad MR;Lazar SW
正念冥想已经被成功地应用于培养自我调节情绪的技能，因为它使用了对体验的当下无偏见的觉知。这种对感觉体验的高度关注和意识被认为可以创造一个最佳的治疗性暴露条件，从而改善消退学习。我们最近证明，在正念训练后，在消亡记忆的上下文恢复过程中，海马区的连接增加。在这里，我们使用为期两天的恐惧条件反射和消退方案，在一项随机对照的纵向研究中，检验了正念训练后海马区结构变化的作用。我们证明了正念训练相关的下丘脑增加和在消除恐惧的情境提取过程中，海马区与枕侧区域的连接性降低之间的联系。此外，我们证明了连通性降低和正念训练后自我报告的焦虑减少之间的联系。这些结果强调了下丘脑在记忆提取过程中控制与背景刺激相互作用的作用，也强调了正念训练可能培养韧性的机制。正念冥想已经被成功地应用于培养自我调节情绪的技能，因为它使用了对体验的当下无偏见的觉知。这种对感觉体验的高度关注和意识被认为可以创造一个最佳的治疗性暴露条件，从而改善消退学习。在这里，我们研究了海马亚区结构变化的作用，并进一步证明了正念训练相关的下丘脑下丘增加与背景提取消除的恐惧期间海马区到枕外侧区域的连接减少之间的联系。此外，我们证明了连通性降低和正念训练后自我报告的焦虑减少之间的联系。这些结果强调了下丘脑在记忆提取过程中与背景刺激相互作用的门控作用，以及正念训练培养韧性的机制。
Mindfulness meditation has successfully been applied to cultivate skills in self‐regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory experience has been postulated to create an optimal therapeutic exposure condition and thereby improve extinction learning. We recently demonstrated increased connectivity in hippocampal circuits during the contextual retrieval of extinction memory following mindfulness training. Here, we examine the role of structural changes in hippocampal subfields following mindfulness training in a randomized controlled longitudinal study using a two‐day fear‐conditioning and extinction protocol. We demonstrate an association between mindfulness training‐related increases in subiculum and decreased hippocampal connectivity to lateral occipital regions during contextual retrieval of extinguished fear. Further, we demonstrate an association between decreased connectivity and decreases in self‐reported anxiety following mindfulness training. The results highlight the role of the subiculum in gating interactions with contextual stimuli during memory retrieval and, also, the mechanisms through which mindfulness training may foster resilience. Mindfulness meditation has successfully been applied to cultivate skills in self‐regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory experience has been postulated to create an optimal therapeutic exposure condition and thereby improve extinction learning. Here, we examine the role of structural changes in hippocampal subfields and further demonstrate an association between mindfulness training‐related increases in subiculum and decreased hippocampal connectivity to lateral occipital regions during contextual retrieval of extinguished fear. Further, we demonstrate an association between decreased connectivity and decreases in self‐reported anxiety following mindfulness training. These results highlight the role of the subiculum in gating interactions with contextual stimuli during memory retrieval and, also, the mechanisms through which mindfulness training fosters resilience.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.2
作者：
Goldin, Philippe R.;Gross, James J.
通讯作者：
Gross, James J.
影响因子：
3.5
作者：
Eriksson, PS
通讯作者：
Eriksson, PS
影响因子：
2.6
作者：
Engstrom, Maria;Pihlsgard, Johan;Soderfeldt, Birgitta
通讯作者：
Soderfeldt, Birgitta