Exploration of the optimal treatment regimes for Esthesioneuroblastoma: a single center experience in China.
Exploration of the optimal treatment regimes for Esthesioneuroblastoma: a single center experience in China.
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感受神经母细胞瘤最佳治疗方案的探索：中国单中心经验
DOI：
10.7150/jca.21605
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发表时间：
2018
影响因子：
3.9
通讯作者：
Ren Y
中科院分区：
文献类型：
--
作者：
Yuan Y;Ye J;Qiu H;Niu S;Wen B;Wang D;Cao X;Ren Y
BACKGROUND: Esthesioneuroblastoma (ENB) is an uncommon neoplasm arising from the olfactory mucosa. The optimal treatment regimen for ENB remains unclear. This study aims to evaluate its clinical features, long-term outcomes and explore optimal treatment patterns. METHODS: Clinical data of consecutive 44 ENB patients were reviewed retrospectively. The correlation between clinical features and treatment approaches were analyzed, with several prognostic factors explored meanwhile. RESULTS: The age of onset of ENB showed a bimodal distribution, with peaks at 10~20 and 50~60 years. The median follow-up time was 84 months (range, 27~198 months).The 5-year overall and progression free survival rates were 42.7% and 39.1%, respectively, with 10-year rates of 28.9% and 21.7% respectively. Overall, 19 patients developed recurrent disease. Patients undergoing surgery combined with adjuvant radiotherapy had significantly higher 5-year overall survival (67.5% vs. 33.3%, P=0.043) and progress-free survival (60.0%vs. 18.7%, P=0.008) than those receiving other treatment approaches. No-Skin-involved ENB was associated with markedly better 5-year overall survival (45.5%vs.0 %, P=0.038) and progress-free survival (31.3% vs. 0 %, P=0.001) compared with skin-involved tumor. CONCLUSIONS: ENB is a rarely malignant tumor with high probability of locoregional recurrence and poor survival. Surgical resection followed by radiotherapy has been shown to achieve optimal local control and overall survival.
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DOI：
10.1097/coc.0b013e31829b5631
发表时间：
2015-06-01
影响因子：
2.6
作者：
Hollen, Tyler R.;Morris, Christopher G.;Mendenhall, William M.
通讯作者：
Mendenhall, William M.
影响因子：
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DOI：
10.1016/s0360-3016(02)02941-3
发表时间：
2002-10-01
影响因子：
7
作者：
Gruber, GN;Laedrach, K;Greiner, R
通讯作者：
Greiner, R
DOI：
10.1002/hed.10247
发表时间：
2003-07-01
影响因子：
2.9
作者：
Monroe, AT;Hinerman, RW;Mendenhall, WM
通讯作者：
Mendenhall, WM
影响因子：
0.9
作者：
Aljumaily RM;Nystrom JS;Wein RO
通讯作者：
Wein RO