Hippo Pathway Key to Ploidy Checkpoint
Hippo Pathway Key to Ploidy Checkpoint
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河马途径是倍性检查点的关键
DOI:
10.1016/j.cell.2014.07.041
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发表时间:
2014-08
期刊:
影响因子:
64.5
通讯作者:
Kun-Liang Guan
中科院分区:
文献类型:
--
作者:
Bin Zhao;Kun-Liang Guan
Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced cell-cycle arrest.
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影响因子:
8
作者:
Aylon, Y.;Yabuta, N.;Besserglick, H.;Buganim, Y.;Rotter, V.;Nojima, H.;Oren, M.
通讯作者:
Oren, M.
影响因子:
64.5
作者:
Kapoor A;Yao W;Ying H;Hua S;Liewen A;Wang Q;Zhong Y;Wu CJ;Sadanandam A;Hu B;Chang Q;Chu GC;Al-Khalil R;Jiang S;Xia H;Fletcher-Sananikone E;Lim C;Horwitz GI;Viale A;Pettazzoni P;Sanchez N;Wang H;Protopopov A;Zhang J;Heffernan T;Johnson RL;Chin L;Wang YA;Draetta G;DePinho RA
通讯作者:
DePinho RA
影响因子:
10.5
作者:
Tschoep, Katrin;Conery, Andrew R.;Dyson, Nicholas
通讯作者:
Dyson, Nicholas
影响因子:
10.5
作者:
Aylon, Yael;Michael, Dan;Oren, Moshe
通讯作者:
Oren, Moshe
影响因子:
64.5
作者:
Shao DD;Xue W;Krall EB;Bhutkar A;Piccioni F;Wang X;Schinzel AC;Sood S;Rosenbluh J;Kim JW;Zwang Y;Roberts TM;Root DE;Jacks T;Hahn WC
通讯作者:
Hahn WC