Role of Redox Signaling and Inflammation in Skeletal Muscle Adaptations to Training.
Role of Redox Signaling and Inflammation in Skeletal Muscle Adaptations to Training.
复制标题
氧化还原信号和炎症在骨骼肌适应训练中的作用。
DOI：
10.3390/antiox5040048
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发表时间：
2016-12-13
期刊：
影响因子：
--
通讯作者：
Ji LL
中科院分区：
文献类型：
--
作者：
Gomez-Cabrera MC;Viña J;Ji LL
运动引起的肌肉损伤的炎症反应已被广泛描述。运动对免疫功能有重要的调节作用。这些效应由多种因素介导，包括促炎细胞因子、经典应激激素和导致细胞再分布的血流动力学效应。正如已经报道的关于氧化应激，炎症可以在骨骼肌中具有有害和有益的影响。在这篇综述中，我们将讨论炎症对骨骼肌蛋白质代谢的作用。具体来说，我们将审查研究表明，治疗与环氧合酶抑制剂调节蛋白质合成反应的一轮阻力运动和训练。了解这些药物的工作原理对于全世界数百万经常服用它们的人来说非常重要。我们还将讨论活性氧和炎性细胞因子在肌肉适应运动中的重要性，以及运动员使用抗氧化剂和抗炎药物以优化其性能所面临的两面，特别是在预期肌肉肥大的时期。
The inflammatory response to exercise-induced muscle damage has been extensively described. Exercise has important modulatory effects on immune function. These effects are mediated by diverse factors including pro-inflammatory cytokines, classical stress hormones, and hemodynamic effects leading to cell redistribution. As has been reported regarding oxidative stress, inflammation can have both detrimental and beneficial effects in skeletal muscle. In this review we will address the role of inflammation on protein metabolism in skeletal muscle. Specifically, we will review studies showing that treatment with cyclooxygenase-inhibiting drugs modulate the protein synthesis response to one bout of resistance exercise and to training. Understanding how these drugs work is important for the millions of individuals worldwide that consume them regularly. We will also discuss the importance of reactive oxygen species and inflammatory cytokines in muscle adaptations to exercise and the Janus faced of the use of antioxidant and anti-inflammatory drugs by athletes for optimizing their performance, especially during the periods in which muscle hypertrophy is expected.
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影响因子：
7.4
作者：
Hansen, JM;Zhang, H;Jones, DP
通讯作者：
Jones, DP
影响因子：
7.4
作者：
Gomez-Cabrera, Mari-Carmen;Domenech, Elena;Vina, Jose
通讯作者：
Vina, Jose
影响因子：
5.9
作者：
Bell, Phillip G.;Walshe, Ian H.;Howatson, Glyn
通讯作者：
Howatson, Glyn
影响因子：
4.8
作者：
Ji, LL;Gomez-Cabrera, MC;Vina, J
通讯作者：
Vina, J
影响因子：
3.6
作者：
Gomez-Cabrera, Mari-Carmen;Martinez, Agustin;Vina, Jose
通讯作者：
Vina, Jose