Comprehensive evaluation of in vitro toxicity of three large-scale produced carbon nanotubes on human Jurkat T cells and a comparison to crocidolite asbestos
Comprehensive evaluation of in vitro toxicity of three large-scale produced carbon nanotubes on human Jurkat T cells and a comparison to crocidolite asbestos
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三种规模化生产的碳纳米管对人Jurkat T细胞的体外毒性综合评价及与青石棉的比较
DOI：
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
H. Krug
中科院分区：
文献类型：
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作者：
Tina Thurnherr;D. Su;L. Diener;G. Weinberg;Pius Manser;N. Pfänder;Rosa Arrigo;M. Schuster;P. Wick;H. Krug
本研究评估了三种工业上相关的多壁碳纳米管（MWNTs）对人Jurkat T细胞的影响，并将其与石棉进行了比较。虽然氧化应激的迹象很明显，但所有测试的mwnt均未观察到明显的急性毒性。mwnt不激活静止的Jurkat细胞，仅轻微刺激活化细胞中细胞因子白介素-2 （IL-2）的释放。与MWNTs类似，鳄鱼石对Jurkat细胞的毒性作用很小，但既不诱导活性氧的形成，也不诱导IL-2信号的改变。这些发现表明，与许多其他细胞类型不同，T细胞对高纵横比颗粒诱导的应激具有相对的抵抗力。
Abstract This study has evaluated the effects of three industrially relevant multi-walled carbon nanotubes (MWNTs) on human Jurkat T cells and compared them to those of crocidolite asbestos. No overt acute toxicity was observed for all MWNTs tested although signs of oxidative stress were evident. MWNTs did not activate resting Jurkat cells and only slightly stimulated the release of the cytokine interleukin-2 (IL-2) in activated cells. Similar to MWNTs, crocidolite had little toxic effects on Jurkat cells but neither induced the formation of reactive oxygen species nor changes in IL-2 signaling. These findings suggest that, in contrast to many other cell types, T cells are relatively resistant to stress induced by high-aspect ratio particles.
影响因子：
10.8
作者：
Zavaleta C;de la Zerda A;Liu Z;Keren S;Cheng Z;Schipper M;Chen X;Dai H;Gambhir SS
通讯作者：
Gambhir SS
影响因子：
3.8
作者：
Mitchell, Leah A.;Gao, Jun;McDonald, Jacob D.
通讯作者：
McDonald, Jacob D.
影响因子：
2.9
作者：
CATHCART, R;SCHWIERS, E;AMES, BN
通讯作者：
AMES, BN