Nonhepatosplenic γδ T-Cell Lymphoma: A Subset of Cytotoxic Lymphomas With Mucosal or Skin Localization
Nonhepatosplenic γδ T-Cell Lymphoma: A Subset of Cytotoxic Lymphomas With Mucosal or Skin Localization
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非肝脾 γδ T 细胞淋巴瘤：粘膜或皮肤定位的细胞毒性淋巴瘤的一个亚型
DOI：
10.1182/blood.v91.5.1723.1723_1723_1731
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发表时间：
1998
期刊：
影响因子：
20.3
通讯作者：
P. Gaulard
中科院分区：
文献类型：
--
作者：
B. Arnulf;C. Copie;M. Delfau;A. Lavergne‐Slove;J. Bosq;J. Wechsler;M. Wassef;C. Matuchansky;B. Epardeau;M. Stern;M. Bagot;F. Reyes;P. Gaulard
人类γδT淋巴细胞是外周血中T细胞的一小部分，与其广泛的特异性相反，它们表现出有限的多样性和组织限制性的谱系。这种T细胞亚群产生的大多数胸腺后肿瘤属于肝脾γδ淋巴瘤实体。只有少数非肝脾γδ淋巴瘤以前被详细描述过。本文报告了11例非肝脾γδ淋巴瘤的临床病理特征。均以黏膜或皮肤为首发表现：鼻腔(n = 3)、胃肠道(n = 3)、皮肤(n = 3)、肺(n = 1)、喉(n = 1)。大多数患者表现为B症状(8/11)，无外周淋巴结肿大和骨髓受累。6例患者既往有慢性抗原暴露史，4例患者有免疫缺陷特征。组织学分类为多形性肿瘤。大多数病例具有上皮亲和血管中心性的特点。肿瘤细胞具有CD2+、CD3+、T细胞受体δ−1+、βF1−表型。CD_5−(9/10)和CD_4−/CD_8−(9/10)或CD_8+(1/10)。所有受试者均检测到克隆性γ链基因重排(9/9)。所有病例均为活化的细胞毒性T细胞胞内抗原-1(TIA-1)+，颗粒酶B+表型。应用原位杂交技术对6例EB病毒(EBV)进行了序列检测。尽管有积极的临床过程，但有3名患者获得了完全缓解，其中一名患者需要进行外周血干细胞移植。非肝脾γδ外周T细胞淋巴瘤是一种活动性细胞毒性淋巴瘤模型，发生于粘膜或皮肤。这些细胞似乎来源于组织限制性γδ淋巴细胞亚群，它们参与宿主上皮表面的监测。根据在至少部分患者中观察到的既往病史，可以认为慢性抗原暴露在这些罕见淋巴瘤的发病机制中所起的作用。
Human γδ T lymphocytes represent a minor subset of T cells in the peripheral blood, which exhibit a limited diversity and a tissue-restricted repertoire in contrast to their broad specificity. Most postthymic neoplasms that arise from this T-cell subpopulation belong to the hepatosplenic γδ lymphoma entity. Only a few cases of nonhepatosplenic γδ lymphomas have been described in detail previously. This study presents the clinicopathologic features of 11 consecutive cases of nonhepatosplenic γδ lymphoma. All were characterized by mucosal or skin initial involvement: nasal cavity (n = 3), gastrointestinal tract (n = 3), skin (n = 3), lung (n = 1), larynx (n = 1). Most patients presented with B symptoms (eight of 11), without peripheral lymphadenopathy and bone marrow involvement. A past history of chronic antigen exposure was noted in six cases, and four patients had features of immune deficiency. On histology, they were classified as pleomorphic tumors. Features of epitheliotropism and angiocentrism was observed in most cases. Tumor cells had a CD2+, CD3+, T-cell receptor (TCR)δ−1+, βF1− phenotype. They were CD5− (9 of 10) and CD4−/CD8− (9 of 10) or CD8+(1 of 10). A clonal γ-chain gene rearrangement was detected in all tested cases (9/9). All cases had an activated cytotoxic T-cell intracellular antigen-1 (TIA-1)+, Granzyme B+ phenotype. Epstein-Barr virus (EBV) sequences were detected in six cases by in situ hybridization (ISH). Despite an aggressive clinical course, complete remission was obtained in three patients, and one of the latter required a peripheral blood stem-cell transplantation. Nonhepatosplenic γδ peripheral T-cell lymphoma can be regarded as a model of activated cytotoxic lymphoma, occurring in mucosae or skin. These appear to be derived from the subpopulation of tissue-restricted γδ lymphocytes, which are involved in the host epithelial surface surveillance. The role of chronic antigen exposure in the pathogenesis of these rare lymphomas can be suggested, in view of the past history observed in at least some patients.
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DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bucy,RP;Chen,CL;Cooper,MD
通讯作者：
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DOI：
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发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Sciammas,R;Johnson,RM;Sperling,AI;Brady,W;Linsley,PS;Spear,PG;Fitch,FW;Bluestone,JA
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Bluestone,JA
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DOI：
--
发表时间：
1996
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kasper,LH;Matsuura,T;Fonseka,S;Arruda,J;Channon,JY;Khan,IA
通讯作者：
Khan,IA
DOI：
10.1073/pnas.93.21.11774
发表时间：
1996-10-15
影响因子：
11.1
作者：
Roberts, SJ;Smith, AL;Hayday, AC
通讯作者：
Hayday, AC
γ/δ T 细胞移植后淋巴增殖性疾病主要发生在脾脏。
影响因子：
3.5
作者：
Ross,CW;Schnitzer,B;Sheldon,S;Braun,DK;Hanson,CA
通讯作者：
Hanson,CA