Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?
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DOI:
10.1186/1757-4749-3-1
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发表时间:
2011-01-31
期刊:
影响因子:
4.2
通讯作者:
Logan AC
Logan AC
中科院分区:
医学3区
文献类型:
--
作者:
Bowe WP;Logan AC

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自从皮肤科医生 John H. Stokes 和 Donald M. Pillsbury 首次提出抑郁、焦虑和痤疮等皮肤病之间重叠的胃肠道机制以来,已经过去了 70 多年。斯托克斯和皮尔斯伯里假设情绪状态可能会改变正常的肠道菌群,增加肠道通透性并导致全身炎症。斯托克斯和皮尔斯伯里提倡的治疗方法之一是培养嗜酸乳杆菌。这种肠-脑-皮肤统一理论的许多方面最近都得到了验证。肠道微生物群和口腔益生菌影响全身炎症、氧化应激、血糖控制、组织脂质含量甚至情绪本身的能力,可能对痤疮具有重要影响。肠道微生物群也可能为正在发展的饮食和痤疮研究提供线索。在这里,我们为痤疮中肠道-大脑-皮肤联系的当代研究和临床意义提供了历史视角。
Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne.
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