Sleep-dependent reconsolidation after memory destabilization in starlings.
Sleep-dependent reconsolidation after memory destabilization in starlings.
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DOI：
10.1038/s41467-018-05518-5
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发表时间：
2018-08-06
影响因子：
16.6
通讯作者：
Margoliash D
中科院分区：
文献类型：
--
作者：
Brawn TP;Nusbaum HC;Margoliash D
再巩固理论将记忆形成描述为一个在不稳定和稳定状态之间循环的持续过程。虽然睡眠对于记忆的最初巩固至关重要，但很少有证据表明睡眠有助于重新巩固。我们现在通过两个实验证明，如果记忆被提取重新激活，睡眠巩固的记忆可能会不稳定。不稳定的记忆，如果在记忆被重新激活之后而不是之前遇到干扰任务，就会受到损害，然后在睡眠后重新巩固。在另外两个实验中，我们提供的证据表明，干扰任务的学习促进了随后的原始记忆的睡眠依赖性增强。这些结果提供了新的洞察记忆处理的复杂机制，以及关键的证据支持的观点，即长期记忆的形成涉及睡眠依赖性巩固，使用依赖性不稳定，睡眠依赖性再巩固的动态过程。睡眠对记忆巩固很重要，但它在再巩固中的作用尚不清楚。在这里，作者在椋鸟中表明，通过睡眠巩固的听觉记忆可能会因提取而不稳定，并因随后的干扰而受损，但经过一夜的睡眠依赖性重新巩固后，记忆恢复并稳定下来。
Reconsolidation theory describes memory formation as an ongoing process that cycles between labile and stable states. Though sleep is critical for the initial consolidation of a memory, there has been little evidence that sleep facilitates reconsolidation. We now demonstrate in two experiments that a sleep-consolidated memory can be destabilized if the memory is reactivated by retrieval. The destabilized memory, which can be impaired if an interference task is encountered after, but not before, the memory is reactivated, is then reconsolidated after sleep. In two additional experiments, we provide evidence suggesting that the learning of the interference task promotes the subsequent sleep-dependent enhancement of the original memory. These results provide novel insight into the complex mechanisms of memory processing, as well as critical evidence supporting the view that long-term memory formation involves a dynamic process of sleep-dependent consolidation, use-dependent destabilization, and sleep-dependent reconsolidation. Sleep is important for memory consolidation but its role in reconsolidation is not known. Here, the authors show in starlings that an auditory memory consolidated by sleep can be destabilized by retrieval and impaired by subsequent interference, but the memory recovers and stabilizes after a night of sleep-dependent reconsolidation.
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影响因子：
2
作者：
Gais, Steffen;Lucas, Brian;Born, Jan
通讯作者：
Born, Jan
影响因子：
64.8
作者：
Derégnaucourt, S;Mitra, PP;Tchernichovski, O
通讯作者：
Tchernichovski, O
影响因子：
2.9
作者：
KARTEN H J
通讯作者：
KARTEN H J
DOI：
10.1523/jneurosci.3295-10.2010
发表时间：
2010-10-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brawn TP;Fenn KM;Nusbaum HC;Margoliash D
通讯作者：
Margoliash D
影响因子：
2
作者：
Brawn, Timothy P.;Fenn, Kimberly M.;Margoliash, Daniel
通讯作者：
Margoliash, Daniel