Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology
Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology
复制标题
基于网络药理学的半夏泻心汤治疗糖尿病胃轻瘫作用机制研究
DOI：
10.1007/s12539-020-00389-1
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
He Mingmin
中科院分区：
文献类型：
--
作者：
Wu Tingchao;Yue Rensong;Li Liang;He Mingmin
In China, Banxia Xiexin decoction (BXD) is applied to treat diabetic gastroparesis (DGP), but its key active ingredients and mechanisms against DGP are unclear. This study is designated to reveal the molecular mechanisms of BXD in treating DGP by adopting a creative approach known as network pharmacology to explore the active ingredients and therapeutic targets of BXD. In our study, 730 differentially expressed genes of DGP were obtained, and 30 potential targets of BXD against DGP were screened out (including ADRB2, DRD1, FOS, MMP9, FOSL1, FOSL2, JUN, MAP2, DRD2, MYC, F3, CDKN1A, IL6, NFKBIA, ICAM1, CCL2, SELE, DUOX2, MGAM, THBD, SERPINE1, ALOX5, CXCL11, CXCL2, CXCL10, RUNX2, CD40LG, C1QB, MCL1, and ADCYAP1). Based on the findings, BXD contains 60 compounds with therapeutic effect on DGP, including the key active ingredients such as quercetin, wogonin, baicalein, beta-sitosterol, and kaempferol. Sixty-eight pathways including TNF signaling pathway, IL-17 signaling pathway, and AGE-RAGE signaling pathway were significantly enriched. In this study, the mechanisms of BXD in treating DGP are affirmed to be a complex network with multi-target and multi-pathway, which provides a reference for future experimental studies.
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DOI：
10.1186/1759-4499-2-2
发表时间：
2010-02-15
期刊：
Automated experimentation
影响因子：
--
作者：
Raman K
通讯作者：
Raman K
DOI：
10.1007/978-3-030-28929-4
发表时间：
2020-02
期刊：
Gastroparesis
影响因子：
--
作者：
Li-Chang Hsing;Kee Wook Jung
通讯作者：
Li-Chang Hsing;Kee Wook Jung
影响因子：
3.1
作者：
L. D. da Silva;R. D. C. V. D. Da Silva-R.-D.-C.-V.-D.-Da-Silva-32910764;Daniele Maria-Ferreira;O. C. Beltrame;J. E. da Silva-Santos;M. F. Werner
通讯作者：
L. D. da Silva;R. D. C. V. D. Da Silva-R.-D.-C.-V.-D.-Da-Silva-32910764;Daniele Maria-Ferreira;O. C. Beltrame;J. E. da Silva-Santos;M. F. Werner
影响因子：
3.5
作者：
Parkman HP;Hallinan EK;Hasler WL;Farrugia G;Koch KL;Calles J;Snape WJ;Abell TL;Sarosiek I;McCallum RW;Nguyen L;Pasricha PJ;Clarke J;Miriel L;Lee L;Tonascia J;Hamilton F;NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
影响因子：
3.1
作者：
Tsuchiya, Yoshihiro;Nozu, Tsukasa;Kumei, Shima;Ohhira, Masumi;Okumura, Toshikatsu
通讯作者：
Okumura, Toshikatsu