Renaming the SARS-CoV-2 Omicron sublineages as SARS-CoV-3 is contrary to nomenclature standards based on evolutionary and serological evidence.
Renaming the SARS-CoV-2 Omicron sublineages as SARS-CoV-3 is contrary to nomenclature standards based on evolutionary and serological evidence.
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DOI：
10.1002/ctm2.924
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发表时间：
2022-06
影响因子：
10.6
通讯作者：
Jiang, Shibo
中科院分区：
文献类型：
--
作者：
Qi, Zhongtian;Wu, Jianbo;Jiang, Shibo
Gretchen Vogel撰写的一篇题为“Omicron的新版本是免疫逃避的大师”的新闻文章于2022年5月10日发表在Science上。她提到了严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）Omicron变异体的所有三个新的亚系，包括BA。4，BA。5首次在南非和英国发现。2.12. 1，目前在美国传播，因为在L452中具有关键的逃逸突变，这可能解释了接种疫苗或BA的血清中中和能力降低。1例感染但已康复的个体。1作者进一步指出，新加坡杜克大学-新加坡国立大学医学院教授兼主任Linfa Wang提议将新的Omicron亚系重新命名为SARS-CoV-3，因为它们具有广泛且引人注目的免疫逃逸特征。[1]毫不奇怪，这个想法在科学界引起了广泛的讨论。一些科学家同意这个建议，但我们和其他人不同意，基于以下理由。在进化上，2株SARS-CoV-2野生型与SARS-CoV和中东呼吸综合征冠状病毒（MERS-CoV）的同源性分别为79%和55%，而与Omicron BA的同源性分别为11%和11%。2，BA。2.12. 1，BA。4，BA。5个亚系分别为99.67%、99.65%、99.62%和99.66%（图1）。因此，拟议的重新命名违背了命名原则，
A news article entitled ‘New versions of Omicron are masters of immune evasion’authored by Gretchen Vogel was published in Science on 10 May 2022. She mentioned all three new sublineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, including BA. 4 and BA. 5 first detected in South Africa and BA. 2.12. 1 now spreading in the United States, as having a key escape mutation in L452, potentially explaining the reduced neutralising capacity in sera from vaccinated or BA. 1-infected-but-recovered individuals. 1 The author further noted that Linfa Wang, Professor and Director at Duke-NUS Medical School in Singapore, proposed renaming the new Omicron sublineages as SARS-CoV-3 based on their broad and dramatic immune escape profile. 1 Not surprisingly, this idea has provoked wide discussion within the scientific community.Some scientists have agreed with this proposal, but we and others do not, based on the following reasoning. Evolutionarily, 2 SARS-CoV-2 wildtype shares approximately 79% and 55% sequence similarity with SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, while its sequence similarities with Omicron BA. 2, BA. 2.12. 1, BA. 4 and BA. 5 sublineages are 99.67%, 99.65%, 99.62% and 99.66%, respectively (Figure 1). Therefore, the proposed renaming is contrary to the principles of nomenclature, as suggested by
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
3.8
作者：
Thammapalo S;Nagao Y;Sakamoto W;Saengtharatip S;Tsujitani M;Nakamura Y;Coleman PG;Davies C
通讯作者：
Davies C
影响因子：
28.3
作者：
Rambaut A;Holmes EC;O'Toole Á;Hill V;McCrone JT;Ruis C;du Plessis L;Pybus OG
通讯作者：
Pybus OG