Inflammatory cytokine levels implicated in Alzheimer's disease moderate the effects of sex on verbal memory performance.
Inflammatory cytokine levels implicated in Alzheimer's disease moderate the effects of sex on verbal memory performance.
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DOI：
10.1016/j.bbi.2020.12.001
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Slavich GM
中科院分区：
文献类型：
--
作者：
Caldwell JZK;Kinney JW;Ritter A;Salazar A;Wong CG;Cordes D;Slavich GM
尽管与男性相比，女性在最初的文字记忆方面具有优势，但一旦确诊，女性患阿尔茨海默病的几率更高，认知能力下降更快。此外，尽管阿尔茨海默病受炎症的影响，而炎症本身具有已知的性别差异，但没有研究调查记忆中的性别差异是否受到外周炎症活动的调节。为了解决这个问题，我们分析了来自109名被诊断为认知正常或患有轻度认知障碍或阿尔茨海默病痴呆的个体（50名女性，法师= 71.62，范围= 55-87）的数据。然后，我们跟踪样本12个月，作为衰老和阿尔茨海默病纵向研究的一部分。在基线时，我们评估了血浆中炎性细胞因子白细胞介素（IL）-1β（IL-1β）、IL-6和肿瘤坏死因子-α（TNF-α）的水平。在基线和12个月时，我们使用Rey听觉言语学习测试评估言语记忆，使用简明视觉空间记忆测试修订版评估非言语记忆。正如假设的那样，对于整个样本，女性表现出比男性更强的语言（但不是非语言）记忆。在女性中，而不是男性，基线时较高的IL-1β与两个时间点的语言学习较差以及12个月时的记忆延迟有关。性别对记忆的影响也因IL-1β水平而异，女性在基线和12个月时都表现出记忆优势，但仅限于低至中等IL-1β水平的女性。因此，高外周炎症水平可能导致与阿尔茨海默病相关的性别特异性记忆脆弱性。
Despite having an initial verbal memory advantage over men, women have greater rates of Alzheimer’s disease and more rapid cognitive decline once diagnosed. Moreover, although Alzheimer’s disease is influenced by inflammation, which itself has known sex differences, no study has investigated whether sex differences in memory are moderated by peripheral inflammatory activity. To address this issue, we analyzed data from 109 individuals (50 women, Mage = 71.62, range = 55–87) diagnosed as cognitively normal, or having mild cognitive impairment or Alzheimer’s disease dementia. We then followed the sample for 12 months, as part of a longitudinal study of aging and Alzheimer’s disease. At baseline, we assessed levels of the inflammatory cytokines interleukin (IL)-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in plasma. At baseline and 12 months, we assessed verbal memory using the Rey Auditory Verbal Learning Test and nonverbal memory using the Brief Visuospatial Memory Test-Revised. As hypothesized, for the full sample, women exhibited stronger verbal (but not nonverbal) memory than men. In women, but not men, higher IL-1β at baseline related to poorer verbal learning across both time points and delayed recall at 12 months. The effect of sex on memory also differed by IL-1β level, with women exhibiting a memory advantage both at baseline and 12 months, but only for those with low-to-moderate IL-1β levels. Therefore, high peripheral inflammation levels may lead to a sex-specific memory vulnerability relevant for Alzheimer’s disease.
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DOI：
10.1016/j.jalz.2018.04.010
发表时间：
2018-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Buckley RF;Mormino EC;Amariglio RE;Properzi MJ;Rabin JS;Lim YY;Papp KV;Jacobs HIL;Burnham S;Hanseeuw BJ;Doré V;Dobson A;Masters CL;Waller M;Rowe CC;Maruff P;Donohue MC;Rentz DM;Kirn D;Hedden T;Chhatwal J;Schultz AP;Johnson KA;Villemagne VL;Sperling RA;Alzheimer's Disease Neuroimaging Initiative;Australian Imaging, Biomarker and Lifestyle study of ageing;Harvard Aging Brain Study
通讯作者：
Harvard Aging Brain Study
DOI：
10.1016/j.bbrc.2013.10.042
发表时间：
2013-11-08
影响因子：
3.1
作者：
Aomatsu, Megumi;Kato, Takayuki;Kitagawa, Seiichi
通讯作者：
Kitagawa, Seiichi
影响因子：
14
作者：
通讯作者：
--
影响因子：
4.8
作者：
Beydoun, May A.;Dore, Gregory A.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
15.1
作者：
Beydoun, May A.;Weiss, Jordan;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.