Exosome-related tumor microenvironment.
Exosome-related tumor microenvironment.
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外泌体相关的肿瘤微环境
DOI：
10.7150/jca.26422
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发表时间：
2018
影响因子：
3.9
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Hu C;Chen M;Jiang R;Guo Y;Wu M;Zhang X
肿瘤微环境（肿瘤细胞所处的内外环境）对肿瘤的发生、生长和转移至关重要。越来越多的研究表明，外泌体与肿瘤微环境密切相关。然而，所涉及的机制尚不清楚。本文就外来体相关的肿瘤微环境及其他相关因素，如缺氧、炎症和血管生成等作一综述。许多研究表明，外泌体是肿瘤微环境中转移、血管生成和免疫调节的重要介质。此外，外泌体可以从肿瘤患者的体液中分离，包括尿液、血液、唾液、乳汁、肿瘤渗出液、脑脊液、羊水等，因此外泌体是潜在的临床预测生物标志物，也是良好的药物载体，因为它们可以穿过生物膜而不引发免疫反应。总的来说，这些发现表明，外泌体对于开发新一代药物疗法的潜在靶点至关重要，这些药物疗法将改善肿瘤微环境。
The tumor microenvironment (tumor cells are located in the internal and external environment) is vital for the occurrence, growth and metastasis of tumors. An increasing number of studies have shown that exosomes are closely related to the tumor microenvironment. The mechanisms involved, however, are unclear. The focus of this review is on the exosome-related tumor microenvironment and other relevant factors, such as hypoxia, inflammation and angiogenesis. Many studies have suggested that exosomes are important mediators of metastasis, angiogenesis, and immune modulation in the tumor microenvironment. Additionally, exosomes can be isolated from bodily fluids of cancer patients, including urine, blood, saliva, milk, tumor effusion, cerebrospinal fluid, amniotic fluid and so on. Consequently, exosomes are potential biomarkers for clinical predictions and are also good drug carriers because they can cross the biofilm without triggering an immune response. Collectively, these findings illustrate that exosomes are crucial for developing potential targets for a new generation of pharmaceutical therapies that would improve the tumor microenvironment.
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DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
影响因子：
4
作者：
Campbell, Elizabeth J.;Vissers, Margreet C. M.;Bozonet, Stephanie;Dyer, Arron;Robinson, Bridget A.;Dachs, Gabi U.
通讯作者：
Dachs, Gabi U.
影响因子：
9.7
作者：
Ivey JW;Bonakdar M;Kanitkar A;Davalos RV;Verbridge SS
通讯作者：
Verbridge SS
影响因子：
7.4
作者：
Chen WL;Wang CC;Lin YJ;Wu CP;Hsieh CH
通讯作者：
Hsieh CH
影响因子：
7.3
作者：
Hendry SA;Farnsworth RH;Solomon B;Achen MG;Stacker SA;Fox SB
通讯作者：
Fox SB