Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex.
Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex.
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DOI：
10.1016/j.neuron.2015.03.014
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发表时间：
2015-04-22
期刊：
影响因子：
16.2
通讯作者：
Froemke, Robert C.
中科院分区：
文献类型：
--
作者：
D'amour, James A.;Froemke, Robert C.
Synapses are plastic and can be modified by changes of spike timing. While most studies of long-term synaptic plasticity focus on excitation, inhibitory plasticity may be critical for controlling information processing, memory storage, and overall excitability in neural circuits. Here we examine spike-timing-dependent plasticity (STDP) of inhibitory synapses onto layer 5 neurons in slices of mouse auditory cortex, together with concomitant STDP of excitatory synapses. Pairing pre- and postsynaptic spikes potentiated inhibitory inputs irrespective of precise temporal order within ~10 msec. This was in contrast to excitatory inputs, which displayed an asymmetrical STDP time window. These combined synaptic modifications both required NMDA receptor activation, and adjusted the excitatory-inhibitory ratio of events paired together with postsynaptic spiking. Finally, subthreshold events became suprathreshold, and the time window between excitation and inhibition became more precise. These findings demonstrate that cortical inhibitory plasticity requires interactions with co-activated excitatory synapses to properly regulate excitatory-inhibitory balance.
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