What is the association of lipid levels and incident stroke?
What is the association of lipid levels and incident stroke?
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DOI：
10.1016/j.ijcard.2016.06.091
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发表时间：
2016-10-01
影响因子：
3.5
通讯作者：
Banach, Maciej
中科院分区：
文献类型：
--
作者：
Glasser, Stephen P.;Mosher, Aleena;Howard, George;Banach, Maciej
血脂水平与卒中发生率之间的相关性小于血脂水平与冠心病（CHD）之间的相关性。评估总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯水平与卒中发生率之间是否存在地理、种族和种族差异。根据卒中地理和种族差异的原因（REGARDS）研究，我们评估了基线时无卒中的参与者的LDL-C、HCL-C、TC、非HDL-C（总HDL-C）和甘油三酯的基线水平。考克斯比例风险模型是主要的分析工具，用于检查中风和血脂之间的关联。对于每个调整的血脂指标（LDL-C、HDL-C、甘油三酯、TC和非HDL-C），我们计算了一系列增量模型。分析队列包括23，867名参与者，平均随访时间为7.5 +/-2.9年，有1031例中心裁定的卒中（874例缺血性卒中和77例出血性卒中）。HDL-C基线水平与总体未校正风险降低13%相关（HR 0.87，95%置信区间[CI]：0.81-0.93; p<0.05;缺血性卒中14%，出血性卒中16%），TC与所有卒中风险降低8%相关（HR 0.92，95%CI：0.87-0.99; p<0.05）。当对结果进行充分校正时，仅观察到LDL-C和非HDL-C与缺血性卒中的显著相关性。当调整年龄、种族、年龄 * 种族、性别、教育、地区或收入时，这些关联没有显著差异。在无疾病人群中，LDL-C和非HDL-C基线水平与缺血性卒中风险显著相关。
The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD) To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C) and triglyceride levels with incident stroke. From The REasons for Geographic AndRacial Differences in Stroke (REGARDS) study we evaluated baseline levels of LDL-C, HCL-C, TC, Non-HDL-C (Total - HDL-C) and triglycerides in participants free of prevalent stroke at baseline. Cox Proportional-Hazard models were the main analytical tool used to examine the association between incident stroke and lipids. For each adjusted lipid measure (LDL-C, HDL-C, triglycerides, TC, and non-HDL-C) we calculated a series of incremental models. The analysis cohort was 23,867 participants with a mean follow-up time of 7.5 +/− 2.9 years, and 1031 centrally adjudicated strokes (874 ischemic and 77 hemorrhagic strokes). HDL-C baseline level was associated with an overall unadjusted 13% risk reduction (HR 0.87, 95% confidence interval [CI]: 0.81–0.93; p<0.05; 14% for ischemic and 16% for hemorrhagic strokes), and TC with an 8% (HR 0.92, 95%CI: 0.87–0.99; p<0.05) risk reduction of all strokes. When the results were fully adjusted a significant association was observed only for LDL-C and non-HDL-C and ischemic stroke. There were no significant differences in these associations when adjusted for age, race, age*race, gender, education, region, or income. In a disease free population, LDL-C and non-HDL-C baseline levels are significantly associated with the risk of ischemic stroke.
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影响因子：
5.4
作者：
Stamler J;Neaton JD;Cohen JD;Cutler J;Eberly L;Grandits G;Kuller LH;Ockene J;Prineas R;MRFIT Research Group
通讯作者：
MRFIT Research Group
影响因子：
120.7
作者：
Freiberg, Jacob J.;Tybjaerg-Hansen, Anne;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.
影响因子：
8.3
作者：
Howard G;Cushman M;Kissela BM;Kleindorfer DO;McClure LA;Safford MM;Rhodes JD;Soliman EZ;Moy CS;Judd SE;Howard VJ;REasons for Geographic And Racial Differences in Stroke (REGARDS) Investigators
通讯作者：
REasons for Geographic And Racial Differences in Stroke (REGARDS) Investigators
影响因子：
37.8
作者：
Patel, A;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
7.7
作者：
Zhang, X;Patel, A;Woodward, M
通讯作者：
Woodward, M