Neuroinflammation, Stem Cells, and Stroke.
Neuroinflammation, Stem Cells, and Stroke.
复制标题
作者：
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the US and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window stands as an urgent need in stroke. The progressive inflammation that occurs centrally and peripherally after stroke serves as a unique therapeutic target to retard and even halt the secondary cell death. Stem cell therapy represents a potent approach that can diminish inflammation in both the stroke brain and periphery (e.g., spleen), advancing a paradigm-shift from a traditionally brain-focused therapy to treating stroke as a neurological disorder with a significant peripheral pathology. The purpose of this review paper is to highlight the inflammation- mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses.
影响因子：
3.7
作者：
Lai Y;Asthana A;Cheng K;Kisaalita WS
通讯作者：
Kisaalita WS
影响因子：
4.8
作者：
Borlongan MC;Farooq J;Sadanandan N;Wang ZJ;Cozene B;Lee JY;Steinberg GK
通讯作者：
Steinberg GK