OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer.
OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer.
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OCT4 表达和血管生成拟态形成与人类乳腺癌的不良预后呈正相关
DOI：
10.3390/ijms151119634
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发表时间：
2014-10-28
影响因子：
5.6
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Liu T;Sun B;Zhao X;Li Y;Gu Q;Dong X;Liu F
为了评估OCT4表达和血管生成模拟（VM）在人乳腺癌中的预后价值，我们采用免疫组织化学和CD31/PAS（周期性酸-席夫）双染色检测了90例乳腺癌标本的OCT4表达和VM形成。所有患者术后随访5 - 149个月。采用Kaplan-Meier法生成生存曲线。采用Cox回归模型进行多因素分析，评估预后价值。结果显示OCT4表达与VM形成呈正相关（p < 0.05）。OCT4表达和VM与淋巴结转移、较高的组织学分级、诺丁汉预后指数呈正相关（p < 0.05）。OCT4表达或VM形成患者的总生存期（OS）和无病生存期（DFS）低于OCT4阴性或VM阴性患者（p < 0.05）。oct4阳性/ vm阳性患者的OS和DFS也最差（p < 0.05）。在多变量生存分析中，VM、诺丁汉预后指数（NPI）和Her2是与OS和oct4阳性/VM阳性患者相关的独立预后因素，而NPI和Her2是DFS的独立预测因子。这些结果表明，OCT4表达/VM联合检测可以提高乳腺癌患者的预后判断。
To evaluate the prognostic value of OCT4 expression and vasculogenic mimicry (VM) in human breast cancer, we examined OCT4 expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-schiff) double staining on 90 breast cancer specimens. All patients were followed up for five–149 months following surgery. Survival curves were generated using Kaplan-Meier method. Multivariate analysis was performed using Cox regression model to assess the prognostic values. Results showed positive correlation between OCT4 expression and VM formation (p < 0.05). Both OCT4 expression and VM were also positively correlated with lymph node metastasis, higher histological grade, and Nottingham prognostic index (p < 0.05). Patients with OCT4 expression or VM formation exhibited poorer overall survival (OS) and disease-free survival (DFS) than OCT4-negative or VM-negative patients (p < 0.05). OCT4-positive/VM-positive patients also had the worst OS and DFS (p < 0.05). In multivariate survival analysis, VM, Nottingham prognostic index (NPI), and Her2 were independent prognostic factors related to OS and OCT4-positive/VM-positive patients, whereas NPI and Her2 were independent predictors of DFS. These results suggest that a combined OCT4 expression/VM could improve the prognostic judgment for breast cancer patients.
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