Streptococcus pneumoniae: 'captain of the men of death' and financial burden.

Streptococcus pneumoniae: 'captain of the men of death' and financial burden.
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DOI:
10.1099/mic.0.001275
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发表时间:
2022-12
期刊:
影响因子:
2.8
通讯作者:
Andrew, Peter W.
Andrew, Peter W.
中科院分区:
生物学4区
文献类型:
--
作者:
Yesilkaya, Hasan;Oggioni, Marco R.;Andrew, Peter W.

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肺炎链球菌可寄生于人体上呼吸道,不会造成危害,但也会引起发病率和死亡率高的疾病。它具有出色的适应能力,这要归功于它能够通过获取和整合其他细菌的DNA来改组其遗传内容,并具有高度的遗传转化能力。糖的感知、切割和运输确保了它在宿主中的适合性和生存,而巨噬细胞的细胞内生存与毒力有关。多糖被膜和毒素溶气素是最重要的毒力决定因素。以多糖为基础的疫苗提供对疫苗配方中所代表的血清型的保护。
Streptococcus pneumoniae may inhabit the upper respiratory tract of humans without causing harm but it also causes diseases with high morbidity and mortality. It has excellent adaptive capabilities thanks to its ability to shuffle its genetic content by acquiring and incorporating DNA from other bacteria and is highly competent for genetic transformation. Sugar sensing, cleavage and transport ensure its fitness and survival in the host, and intracellular survival in macrophages has been linked to virulence. The polysaccharide capsule and toxin pneumolysin are the most important virulence determinants. Polysaccharide-based vaccines provide protection against the serotypes represented in vaccine formulations.
DOI: 10.7717/peerj.2477
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