Reduced tissue-level stiffness and mineralization in osteoporotic cancellous bone.
Reduced tissue-level stiffness and mineralization in osteoporotic cancellous bone.
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DOI：
10.1007/s00223-014-9873-4
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发表时间：
2014-08
影响因子：
4.2
通讯作者：
van der Meulen, Marjolein C. H.
中科院分区：
文献类型：
--
作者：
Kim, Grace;Cole, Jacqueline H.;Boskey, Adele L.;Baker, Shefford P.;van der Meulen, Marjolein C. H.
骨质疏松症改变骨量和组成，最终增加主要松质骨部位的脆性;然而，骨质疏松症对松质骨组织水平力学性能的影响尚不清楚。双能X线骨密度仪（DXA）扫描是诊断骨质疏松症的临床标准，尽管使用该方法很难将松质骨质量和矿化的变化分开。本研究的目的是调查组织水平的属性与骨质疏松症的供体T-评分定义的可能差异。使用来自高加索女性尸体（58-92岁）的脊柱节段。根据DXA扫描计算每个供体的T评分，以确定肾脏病状态。使用纳米压痕和拉曼光谱测量邻近扫描区域的椎骨的组织水平组成和机械性能。根据T评分，6份样本属于骨质疏松组（58-74岁），4份样本属于非骨质疏松组（65-92岁）。骨质疏松组的压痕模量和矿物质与基质比（矿物质：基质）低于非骨质疏松组。矿物质：基质比随年龄增加而降低（r2 = 0.35，p = 0.05），压痕模量随真实的骨矿物质密度（aBMD）增加而增加（r2 = 0.41，p = 0.04）。这项研究是第一次检查松质骨的组成和力学性能，从骨折易发部位与骨质疏松症。我们发现，骨质疏松症的组织成分和机械性能的差异，除了骨小梁结构和骨体积的变化外，还可能导致脆性增加。
Osteoporosis alters bone mass and composition ultimately increasing the fragility of primarily cancellous skeletal sites; however, effects of osteoporosis on tissue-level mechanical properties of cancellous bone are unknown. Dual-energy x-ray absorptiometry (DXA) scans are the clinical standard for diagnosing osteoporosis though changes in cancellous bone mass and mineralization are difficult to separate using this method. The goal of this study was to investigate possible difference in tissue-level properties with osteoporosis as defined by donor T-scores. Spine segments from Caucasian female cadavers (58–92 yrs) were used. A T-score for each donor was calculated from DXA scans to determine osteoporotic status. Tissue level composition and mechanical properties of vertebrae adjacent to the scan region were measured using nanoindentation and Raman spectroscopy. Based on T-scores, six samples were in the Osteoporotic group (58–74 yrs) and four samples were in the Not Osteoporotic group (65–92 yrs). The indentation modulus and mineral to matrix ratio (mineral:matrix) were lower in the Osteoporotic group than the Not Osteoporotic group. Mineral:matrix ratio decreased with age (r2 = 0.35, p = 0.05), and the indentation modulus increased with a real bone mineral density (aBMD) (r2 = 0.41, p = 0.04). This study is the first to examine cancellous bone composition and mechanical properties from a fracture prone location with osteoporosis. We found differences in tissue composition and mechanical properties with osteoporosis that could contribute to increased fragility in addition to changes in trabecular architecture and bone volume.
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影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
6.2
作者：
Gourion-Arsiquaud, Samuel;Faibish, Dan;Boskey, Adele L.
通讯作者：
Boskey, Adele L.
影响因子：
4.2
作者：
Fratzl-Zelman, N.;Roschger, P.;Gourrier, A.;Weber, M.;Misof, B. M.;Loveridge, N.;Reeve, J.;Klaushofer, K.;Fratzl, P.
通讯作者：
Fratzl, P.
影响因子：
4.2
作者：
Carden, A;Rajachar, RM;Kohn, DH
通讯作者：
Kohn, DH