Sindbis virus maturation in cultured mosquito cells is sensitive to actinomycin D.

Sindbis virus maturation in cultured mosquito cells is sensitive to actinomycin D.
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辛德比斯病毒在培养的蚊子细胞中成熟,对放线菌素 D 敏感。

DOI:
10.1016/0042-6822(81)90061-1
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发表时间:
1981
期刊:
影响因子:
3.7
通讯作者:
Brown,DT
Brown,DT
中科院分区:
医学3区
文献类型:
--
作者:
Scheefers-Borchel,U;Scheefers,H;Edwards,J;Brown,DT

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In contrast to its effects on Sindbis virus production in vertebrate cell cultures, actinomycin D was found to inhibit the production of virus in culturedAedes albopictuscells andBombyx moricells. One to two hours of incubation in the presence of actinomycin D was required for the inhibition to be observed. Synthesis and processing of virus structural polypeptides were found to be normal during the period of arrest of virus production. These data are interpreted as indicating the presence of a labile host function involved in the assembly of Sindbis virus components into mature virus in invertebrate host cells.
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