Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada.
Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada.
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DOI：
10.1186/1475-2891-11-18
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发表时间：
2012-03-26
影响因子：
5.4
通讯作者：
Parfrey PS
中科院分区：
文献类型：
--
作者：
Sun Z;Liu L;Wang PP;Roebothan B;Zhao J;Dicks E;Cotterchio M;Buehler S;Campbell PT;McLaughlin JR;Parfrey PS
饮食被认为是与结直肠癌（CRC）风险相关的最重要的环境因素之一。最近的一份报告全面得出结论，总能量摄入量与结直肠癌风险没有简单的关系，并且碳水化合物、胆固醇和蛋白质的数据不一致。本研究的目的是利用在加拿大纽芬兰和拉布拉多省（NL）和安大略省（ON）进行的一项大型病例对照研究的数据，确定结直肠癌风险与总能量、蛋白质、脂肪、碳水化合物、纤维和酒精的饮食摄入量之间的关系。结直肠癌病例（n = 1760）是从安大略省（1997-2000 年）和荷兰省（1999-2003 年）基于人口的癌症登记处确定的。对照组 (n = 2481) 是每个省份居民的随机样本，年龄在 20-74 岁之间。使用家族史问卷（FHQ）、个人史问卷（PHQ）和食物频率问卷（FFQ）来收集研究数据。使用逻辑回归来评估总能量、大量营养素和酒精的摄入量与结直肠癌风险的关系。总能量摄入量与较高的 CRC 风险相关（OR：1.56；95% CI：1.21-2.01，p 趋势 = 0.02，第五与第一五分位数），而蛋白质摄入量则出现负相关（OR：0.85，95% CI：0.69-1.00，p 趋势 = 0.06，第五与第一五分位数）五分之一）、碳水化合物（OR：0.81，95% CI：0.63-1.00，p 趋势 = 0.05，第五与第一五分之一）和总膳食纤维（OR：0.84，95% CI：0.67-0.99，p 趋势 = 0.04，第五与第一五分之一）。总脂肪、酒精、饱和脂肪酸、单不饱和脂肪酸、多不饱和脂肪酸和胆固醇与结直肠癌风险无关。这项研究提供了进一步的证据，表明高能量摄入可能会增加患结直肠癌的风险，而富含蛋白质、纤维和碳水化合物的饮食可能会降低患结直肠癌的风险。
Diet is regarded as one of the most important environmental factors associated with colorectal cancer (CRC) risk. A recent report comprehensively concluded that total energy intake does not have a simple relationship with CRC risk, and that the data were inconsistent for carbohydrate, cholesterol and protein. The objective of this study was to identify the associations of CRC risk with dietary intakes of total energy, protein, fat, carbohydrate, fiber, and alcohol using data from a large case-control study conducted in Newfoundland and Labrador (NL) and Ontario (ON), Canada. Incident colorectal cancer cases (n = 1760) were identified from population-based cancer registries in the provinces of ON (1997-2000) and NL (1999-2003). Controls (n = 2481) were a random sample of residents in each province, aged 20-74 years. Family history questionnaire (FHQ), personal history questionnaire (PHQ), and food frequency questionnaire (FFQ) were used to collect study data. Logistic regression was used to evaluate the association of intakes of total energy, macronutrients and alcohol with CRC risk. Total energy intake was associated with higher risk of CRC (OR: 1.56; 95% CI: 1.21-2.01, p-trend = 0.02, 5th versus 1st quintile), whereas inverse associations emerged for intakes of protein (OR: 0.85, 95%CI: 0.69-1.00, p-trend = 0.06, 5th versus 1st quintile), carbohydrate (OR: 0.81, 95%CI: 0.63-1.00, p-trend = 0.05, 5th versus 1st quintile) and total dietary fiber (OR: 0.84, 95% CI:0.67-0.99, p-trend = 0.04, 5th versus 1st quintile). Total fat, alcohol, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol were not associated with CRC risk. This study provides further evidence that high energy intake may increase risk of incident CRC, whereas diets high in protein, fiber, and carbohydrate may reduce the risk of the disease.
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影响因子：
13.5
作者：
Longato, Lisa;de la Monte, Suzanne;Kuzushita, Noriyoshi;Horimoto, Masayoshi;Rogers, Arlin B.;Slagle, Betty L.;Wands, Jack R.
通讯作者：
Wands, Jack R.
影响因子：
24.5
作者：
Dray, X;Boutron-Ruault, MC;Faivre, J
通讯作者：
Faivre, J
影响因子：
3.6
作者：
Kurotani, Kayo;Budhathoki, Sanjeev;Terasaka, Reiji
通讯作者：
Terasaka, Reiji
影响因子：
13.8
作者：
Longo VD;Fontana L
通讯作者：
Fontana L
影响因子：
8.4
作者：
Gonzalez, Carlos A.;Riboli, Elio
通讯作者：
Riboli, Elio