Thirst and sodium appetite after colloid treatment in rats: role of the renin-angiotensin-aldosterone system.
Thirst and sodium appetite after colloid treatment in rats: role of the renin-angiotensin-aldosterone system.
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大鼠胶体治疗后的口渴和钠食欲：肾素-血管紧张素-醛固酮系统的作用。
DOI：
10.1037//0735-7044.97.5.725
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发表时间：
1983
影响因子：
1.9
通讯作者：
Stricker,EM
中科院分区：
文献类型：
--
作者：
Stricker,EM
最近的实验表明，大鼠通常在sc注射聚乙二醇(PEG)溶液5小时后出现钠摄取。低钠饲料喂养2~4天后，大鼠的食欲在30~60分钟内出现。在这两种情况下，醛固酮水平的升高与氯化钠摄入量的出现是平行的。在本实验中，65只雄性白化SD大鼠，在预先切除脑垂体部阻止给药后的醛固酮高分泌的情况下，不再通过低钠饮食的预维持来增强钠的食欲。相反，当血管紧张素II(AII)在大脑中异常大量产生时，由于全身应用卡托普利，聚乙二醇组SS患者的钠食欲增强。即使在不喝水，血浆钠浓度显著升高的情况下，后一种效应也会发生。这些和其他发现提出了这样一种可能性，即在经过聚乙二醇化处理后，大鼠体内正常的醛固酮分泌可能允许生理剂量的AII有效地刺激钠的食欲。这些行动将补充公认的肾素-血管紧张素-醛固酮系统在维持血压和钠平衡方面的生理作用。
Recent experiments indicated that rats usually develop sodium appetite 5 hrs after sc injection of polyethylene glycol (PEG) solution. However, sodium appetite appeared within 30–60 min if the rats had been maintained on sodium-deficient diet instead of Purina chow for 2–4 days previously. Elevated levels of aldosterone paralleled the appearance of NaCl consumption in both circumstances. In the present experiments, with 65 male albino Sprague-Dawley rats, sodium appetite was no longer potentiated by pretreatment maintenance on sodium-deficient diet when the hypersecretion of aldosterone after PEG administration was prevented by prior hypophysectomy. Conversely, sodium appetite was enhanced in PEG-treated Ss when angiotensin II (AII) was produced in unusually large amounts in the brain, owing to the systemic administration of captopril. This latter effect occurred even when drinking water was withheld and plasma sodium concentrations were markedly elevated. These and other findings raise the possibility that the normal secretion of aldosterone in rats after PEG treatment might permit physiological amounts of AII to be effective in stimulating sodium appetite. Such actions would complement the accepted physiological role of the renin-angiotensin-aldosterone system in the maintenance of blood pressure and sodium balance.(45 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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肾素-血管紧张素系统和口渴：重新评估。
影响因子：
56.9
作者：
E. Stricker;W. Bradshaw;R. Mcdonald
通讯作者：
R. Mcdonald
脑室内输注血管紧张素II可抑制醛固酮分泌。
影响因子：
--
作者：
V. Brooks;R. Malvin
通讯作者：
R. Malvin
第 14 章 – 钠食欲的生理基础：“消耗-补充”模型的新视角
DOI：
--
发表时间：
1980
期刊：
影响因子：
--
作者：
E. Stricker
通讯作者：
E. Stricker
急性缺钠后垂体切除大鼠的钠平衡恢复。
影响因子：
2.9
作者：
J. Jalowiec;E. Stricker;G. Wolf
通讯作者：
G. Wolf
肾素-血管紧张素系统和口渴：重新评估。
DOI：
--
发表时间：
1977
期刊：
Journal of Comparative and Physiological Psychology
影响因子：
--
作者：
E. Stricker
通讯作者：
E. Stricker