Southeast Asian diversity: first insights into the complex mtDNA structure of Laos.
Southeast Asian diversity: first insights into the complex mtDNA structure of Laos.
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DOI：
10.1186/1471-2148-11-49
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发表时间：
2011-02-18
影响因子：
3.4
通讯作者：
Parson W
中科院分区：
文献类型：
--
作者：
Bodner M;Zimmermann B;Röck A;Kloss-Brandstätter A;Horst D;Horst B;Sengchanh S;Sanguansermsri T;Horst J;Krämer T;Schneider PM;Parson W
大规模的移民和随后的同化过程塑造了东南亚的基因组成，这是几个主要民族之间密切联系的地区。为了更好地表征该区域的遗传变异，我们根据最高的法医质量标准分析了214名来自老挝的非亲属供体的整个mtDNA控制区。为了详细说明系统发育，我们检查了mtDNA编码区选择的snp。为了进行事后数据质量控制，进行了准中位数网络构建和常染色体STR分型。为了更全面地描述老挝人的mtDNA结构，我们将这些数据与16个东亚群体进行了群体遗传比较。老挝样本显示出充足的mtDNA多样性，反映了所列民族的数量之多。我们在这个数据集和周围人群中发现了几个新的，迄今为止未描述的mtDNA谱系。老挝居群在单倍型组成和遗传结构方面具有一定的特征，但与其他东南亚居群的遗传比较显示出有限但显著的遗传分化。在东南亚主要土著民族语言群体的母系关系中发现了显著差异。在这项研究中，我们首次描绘了老挝巨大的mtDNA多样性。我们的发现将有助于澄清该地区的移民历史。他们鼓励建立区域和亚人口数据库，特别是用于法医应用。老挝的序列在出版后将被纳入EMPOP mtDNA合作数据库http://www.empop.org，并将作为该国的第一个mtDNA参考数据。
Vast migrations and subsequent assimilation processes have shaped the genetic composition of Southeast Asia, an area of close contact between several major ethnic groups. To better characterize the genetic variation of this region, we analyzed the entire mtDNA control region of 214 unrelated donors from Laos according to highest forensic quality standards. To detail the phylogeny, we inspected selected SNPs from the mtDNA coding region. For a posteriori data quality control, quasi-median network constructions and autosomal STR typing were performed. In order to describe the mtDNA setup of Laos more thoroughly, the data were subjected to population genetic comparisons with 16 East Asian groups. The Laos sample exhibited ample mtDNA diversity, reflecting the huge number of ethnic groups listed. We found several new, so far undescribed mtDNA lineages in this dataset and surrounding populations. The Laos population was characteristic in terms of haplotype composition and genetic structure, however, genetic comparisons with other Southeast Asian populations revealed limited, but significant genetic differentiation. Notable differences in the maternal relationship to the major indigenous Southeast Asian ethnolinguistic groups were detected. In this study, we portray the great mtDNA variety of Laos for the first time. Our findings will contribute to clarify the migration history of the region. They encourage setting up regional and subpopulation databases, especially for forensic applications. The Laotian sequences will be incorporated into the collaborative EMPOP mtDNA database http://www.empop.org upon publication and will be available as the first mtDNA reference data for this country.
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影响因子：
3.1
作者：
Irwin, Jodi A.;Saunier, Jessica L.;Parsons, Thomas J.
通讯作者：
Parsons, Thomas J.
影响因子：
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作者：
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Richards, M
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3.1
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通讯作者：
Bandelt, Hans-Juergen
影响因子：
2.1
作者：
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通讯作者：
Parsons, Thomas J.
影响因子：
56.9
作者：
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Zilfalil, Bin Alwi