Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches.

Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches.
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DOI:
10.1016/j.conb.2016.09.010
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发表时间:
2016-12
影响因子:
5.7
通讯作者:
Stanhope ME
Stanhope ME
中科院分区:
医学2区
文献类型:
--
作者:
Dickinson PS;Qu X;Stanhope ME

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中心模式发生器受多肽调制,允许灵活的模式输出。目前用于表征肽的技术包括质谱法和转录组学。近年来,数百种神经肽已从甲壳类动物中测序;质谱法已被用于鉴定肽并确定其水平和位置,为研究肽的生理作用的比较研究奠定了基础。这些研究表明,即使在一个物种内,也存在一些功能的进化守恒,但也存在功能的分化。有了目前的基线数据,应该有可能开始使用比较的方法来提出一些基本的问题,比如肽为什么是这样编码的,以及这是如何影响神经系统功能的。
Central pattern generators are subject to modulation by peptides, allowing for flexibility in patterned output. Current techniques used to characterize peptides include mass spectrometry and transcriptomics. In recent years, hundreds of neuropeptides have been sequenced from crustaceans; mass spectrometry has been used to identify peptides and to determine their levels and locations, setting the stage for comparative studies investigating the physiological roles of peptides. Such studies suggest that there is some evolutionary conservation of function, but also divergence of function even within a species. With current baseline data, it should be possible to begin using comparative approaches to ask fundamental questions about why peptides are encoded the way that they are and how this affects nervous system function.
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