A critical appraisal of radiographic scoring systems for assessment of juvenile idiopathic arthritis
A critical appraisal of radiographic scoring systems for assessment of juvenile idiopathic arthritis
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用于评估幼年特发性关节炎的放射照相评分系统的严格评估
DOI：
10.1007/s00247-005-0073-2
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发表时间：
2006
影响因子：
2.3
通讯作者：
B. Feldman
中科院分区：
文献类型：
--
作者：
A. Doria;P. Babyn;B. Feldman
随着时间的推移，评估关节的结构损伤对于评估炎性关节炎患者治疗干预的有效性至关重要。虽然x线摄影能够量化关节损伤，但在病程早期常规x线摄影发现的变化是非特异性的，而后期x线摄影的变化通常是不可逆的。尽管许多儿童药物开发的临床试验仍然使用放射学量表作为研究的终点，但针对青少年特发性关节炎（JIA）的更具体的治疗方法已经开发出来，使成像能够“微调”患者，使其进入特定的治疗算法。因此，显然需要新的成像尺度来识别早期异常。世界各地的许多儿童风湿病中心坚持使用成人设计的放射学评分系统来评估JIA的进展。很少有儿科靶向放射学量表可用于评估生长关节中JIA的进展，并且这些量表的临床测量和心理测量特性的研究很少。我们对夏普放射学方法的van der Heijde修改的评估、鉴别和预测作用提出了批评，该方法最初设计用于评估成人类风湿关节炎关节损伤，当它应用于儿科人群时。我们讨论了这种用于评估生长关节的放射评分系统的优点和缺点，以及MRI克服传统放射照相不足的能力。
Assessing structural damage to joints over time is essential for evaluating the effectiveness of therapeutic interventions for patients with inflammatory arthritis. Although radiography is able to quantify joint damage, the changes found with conventional radiography early in the disease course are nonspecific, and late radiographic changes are often irreversible. Although many clinical trials on drug development for children still use radiographic scales as endpoints for the study, more specific therapies have been developed for juvenile idiopathic arthritis (JIA) that would enable imaging to “fine-tune” patients to placement into specific treatment algorithms. As a result, new imaging scales to identify early abnormalities are clearly needed. Many pediatric rheumatology centers around the world persistently apply adult-designed radiographic scoring systems to evaluate the progression of JIA. Few pediatric-targeted radiographic scales are available for assessment of progression of JIA in growing joints, and the clinimetric and psychometric properties of such scales have been poorly investigated. We present a critique to the evaluative, discriminative, and predictive roles of the van der Heijde modification of Sharp’s radiographic method, a scale originally designed to assess damage to joints of adults with rheumatoid arthritis, when it is applied to a pediatric population. We discuss the advantages and drawbacks of this radiographic scoring system for assessing growing joints and the ability of MRI to overcome inadequacies of conventional radiography.
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幼年类风湿性关节炎的磁共振成像。
影响因子：
5
作者：
Graham,TB;Blebea,JS;Gylys-Morin,V;Passo,MH
通讯作者：
Passo,MH
DOI：
--
发表时间：
1998-10
期刊：
The Journal of rheumatology
影响因子：
--
作者：
R. Petty;T. Southwood;J. Baum;E. Bhettay;D. Glass;P. Manners;J. Maldonado-Cocco;M. Suarez‐Almazor-M.-Suarez‐Alm
通讯作者：
R. Petty;T. Southwood;J. Baum;E. Bhettay;D. Glass;P. Manners;J. Maldonado-Cocco;M. Suarez‐Almazor-M.-Suarez‐Alm
对参加风湿性疾病计划随机临床试验（甲氨蝶呤、金诺芬或两者组合）的合作系统研究的类风湿性关节炎患者的疾病进展进行放射学评估。
影响因子：
--
作者：
López-Méndez,A;Daniel,WW;Reading,JC;Ward,JR;Alarcón,GS
通讯作者：
Alarcón,GS
影响因子：
39.2
作者：
PINCUS, T;CALLAHAN, LF;KAYE, JJ
通讯作者：
KAYE, JJ