Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner.
Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner.
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DOI：
10.3389/fnbeh.2023.1128586
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发表时间：
2023
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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在发育过程中，生命早期压力（ELS）会损害认知、学习和情绪调节，部分原因是破坏这些高阶功能区域的神经回路。此外，我们最近的工作表明，ELS 还改变了简单的感官知觉：ELS 损害了听觉感知和声音短间隙的神经编码，这对于声音交流至关重要。高阶和基本感觉干扰的结合表明 ELS 可能会影响通信信号的感知和解释。我们通过测量 ELS 和未经治疗的蒙古沙鼠对同种发声（其他沙鼠发出的声音）的行为反应来检验这一假设。由于压力的影响通常因性别而异，因此我们分别对女性和男性进行了研究。为了诱导 ELS，从产后第 9-24 天（P），听觉皮层对外部干扰最敏感的时间窗口开始，幼崽被间歇性地与母体分开并受到限制。我们测量了幼年沙鼠（P31-32）对两种类型的同种声音的接近反应：警报叫声，发出警告其他沙鼠潜在的威胁，以及亲社会接触叫声，在熟悉的沙鼠附近发出，特别是在分离后。雄性对照、雌性对照和 ELS 雌性靠近发出预先录制的警报叫声的扬声器，而 ELS 雄性则避开这个来源，这表明 ELS 影响雄性沙鼠对警报叫声的反应。在播放预先录制的接触呼叫过程中，控制组女性和 ELS 男性避开了声源，而控制组男性既不接近也不回避，而 ELS 女性靠近声音。这些差异不能用运动或基线唤醒的变化来解释。然而，ELS 沙鼠在回放过程中睡得更多，这表明 ELS 可能会减少发声回放过程中的唤醒。此外，在工作记忆测量方面，雄性沙鼠比雌性沙鼠犯更多错误，但在这种情况下认知的性别差异可能源于新奇厌恶而不是记忆受损。这些数据表明，ELS 以特定性别的方式影响对行为学相关的交流声音的行为反应，并且是第一个证明 ELS 后对听觉刺激的反应发生改变的数据。这种变化可能是由于听觉感知、认知或多种因素的组合的差异引起的，这表明 ELS 可能会影响人类青少年的听觉交流。
During development, early-life stress (ELS) impairs cognition, learning, and emotional regulation, in part by disrupting neural circuitry in regions underlying these higher-order functions. In addition, our recent work indicates that ELS also alters simple sensory perception: ELS impaired auditory perception and neural encoding of short gaps in sounds, which are essential for vocal communication. The combination of higher-order and basic sensory disruption suggests that ELS is likely to affect both the perception and interpretation of communication signals. We tested this hypothesis by measuring behavioral responses to conspecific vocalizations (those emitted by other gerbils) in ELS and untreated Mongolian gerbils. Because stress effects often differ by sex, we separately examined females and males. To induce ELS, pups were intermittently maternally separated and restrained from post-natal days (P) 9–24, a time window when the auditory cortex is most sensitive to external disruption. We measured the approach responses of juvenile (P31–32) gerbils to two types of conspecific vocalizations: an alarm call, which is emitted to alert other gerbils of a potential threat, and the prosocial contact call, which is emitted near familiar gerbils, especially after separation. Control males, Control females, and ELS females approached a speaker emitting pre-recorded alarm calls, while ELS males avoided this source, suggesting that ELS affects the response to alarm calls in male gerbils. During playback of the pre-recorded contact call, Control females and ELS males avoided the sound source, while Control males neither approached nor avoided, and ELS females approached the sound. These differences cannot be accounted for by changes in locomotion or baseline arousal. However, ELS gerbils slept more during playback, suggesting that ELS may reduce arousal during vocalization playback. Further, male gerbils made more errors than females on a measure of working memory, but the sex difference of cognition in this context may stem from novelty aversion rather than impaired memory. These data indicate that ELS influences behavioral responses to ethologically relevant communication sounds in a sex-specific manner, and are among the first to demonstrate an altered response to auditory stimuli following ELS. Such changes may arise from differences in auditory perception, cognition, or a combination of factors, and suggest that ELS may affect auditory communication in human adolescents.
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影响因子：
2.2
作者：
Cyrenne, De-Laine M.;Brown, Gillian R.
通讯作者：
Brown, Gillian R.
影响因子：
3.7
作者：
通讯作者：
--
影响因子：
3.3
作者：
Eiland, L.;Romeo, R. D.
通讯作者：
Romeo, R. D.
影响因子：
3.5
作者：
Pérez-Valenzuela C;Gárate-Pérez MF;Sotomayor-Zárate R;Delano PH;Dagnino-Subiabre A
通讯作者：
Dagnino-Subiabre A
影响因子：
1.4
作者：
Bialy, Michal;Podobinska, Martyna;Sajdel-Sulkowska, Elzbieta M.
通讯作者：
Sajdel-Sulkowska, Elzbieta M.