Cortical complexity in world trade center responders with chronic posttraumatic stress disorder.
Cortical complexity in world trade center responders with chronic posttraumatic stress disorder.
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DOI：
10.1038/s41398-021-01719-7
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发表时间：
2021-11-23
影响因子：
6.8
通讯作者：
Luft BJ
中科院分区：
文献类型：
--
作者：
Kritikos M;Clouston SAP;Huang C;Pellecchia AC;Mejia-Santiago S;Carr MA;Kotov R;Lucchini RG;Gandy SE;Bromet EJ;Luft BJ
大约23%的世界贸易中心（WTC）响应者正在经历与他们在2001年9月11日恐怖袭击后在WTC的暴露相关的慢性创伤后应激障碍（PTSD），这已被证明是认知障碍的风险因素，引起了对他们大脑健康的担忧。通过分析T1 MRI脑图像的分形维数（FD）测量的皮质复杂性已被报道在各种精神和神经疾病中降低。在这份报告中，我们假设，FD也将减少在一个病例对照样本的99 WTC响应者作为WTC相关的PTSD的结果。我们的基于表面的形态学聚类分析的结果发现，在WTC响应者与PTSD的复杂性的顶点集群的改变，与额叶，顶叶和颞叶皮质内的区域显着减少，除了全脑绝对双边和单边的复杂性。此外，感兴趣区域分析确定，区域FD严重程度的变化幅度与PTSD症状（再体验，回避，过度觉醒，负面影响）严重程度的增加相关。本研究证实了先前关于FD和精神疾病的研究结果，并扩展了我们对FD与创伤后症状严重程度相关性的理解。导致WTC相关PTSD的复杂和创伤性经历与皮质复杂性的降低有关。未来的工作需要确定是否减少皮质的复杂性之前，或同时出现，PTSD的发病。
Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following the terrorist attacks of 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding their brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T1 MRI brain images, has been reported to be reduced in a variety of psychiatric and neurological conditions. In this report, we hypothesized that FD would be also reduced in a case-control sample of 99 WTC responders as a result of WTC-related PTSD. The results of our surface-based morphometry cluster analysis found alterations in vertex clusters of complexity in WTC responders with PTSD, with marked reductions in regions within the frontal, parietal, and temporal cortices, in addition to whole-brain absolute bilateral and unilateral complexity. Furthermore, region of interest analysis identified that the magnitude of changes in regional FD severity was associated with increased PTSD symptoms (reexperiencing, avoidance, hyperarousal, negative affect) severity. This study confirms prior findings on FD and psychiatric disorders and extends our understanding of FD associations with posttraumatic symptom severity. The complex and traumatic experiences that led to WTC-related PTSD were associated with reductions in cortical complexity. Future work is needed to determine whether reduced cortical complexity arose prior to, or concurrently with, onset of PTSD.
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发表时间：
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影响因子：
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作者：
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