Crohn's disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan.
Crohn's disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan.
复制标题
DOI：
10.1007/s00535-018-1482-y
复制
发表时间：
2019-01
影响因子：
6.3
通讯作者：
Washio M
中科院分区：
文献类型：
--
作者：
Yasukawa S;Matsui T;Yano Y;Sato Y;Takada Y;Kishi M;Ono Y;Takatsu N;Nagahama T;Hisabe T;Hirai F;Yao K;Ueki T;Higashi D;Futami K;Sou S;Sakurai T;Yao T;Tanabe H;Iwashita A;Washio M
在这项研究中，在三级转诊中心调查了克罗恩病（CD）患者的生存率和死亡原因。基于我院就诊的1108例CD患者的病历建立数据库，调查其背景特征、诊断累积生存率、死亡原因和每种死亡原因的标准化死亡率（SMR）。对随访不充分的患者进行随访问卷调查。使用生命表法确定诊断后的累积生存率，并与2000年以来性别和年龄匹配的人口模型进行比较。研究纳入1108例患者，平均诊断年龄为25.6±10.8岁。平均随访时间14.6±9.4年，死亡52例。诊断为CD后25年的累积生存率（91.7%）明显低于标准人群模型（95.7%）。所有原因的smr [3.5；95%可信区间（CI）： 2.7-4.6]和cd特异性原因（36.7;95% CI 26.1-51.6）较高。在cd特异性病因中，小肠和结直肠癌、胃肠道疾病（包括肠衰竭（IF））、围手术期并发症和淀粉样变性的smr特别高。所有原因和CD特异性原因的smr在CD患者中都很高。包括肠癌、IF、围手术期并发症和淀粉样变性在内的cd特异性原因显示出特别高的smr。
In this study, survival and cause of death were investigated in patients with Crohn’s disease (CD) at a tertiary referral center. A database was created based on the medical records of 1108 CD patients who had a history of visiting our hospital to investigate background characteristics, cumulative survival rates from diagnosis, causes of death, and the standardized mortality ratio (SMR) for each cause of death. A follow-up questionnaire survey of patients followed up inadequately was also conducted. The cumulative survival rate from diagnosis was determined using the life table method and compared with that of a sex- and age-matched population model from the year 2000. The study included 1108 patients whose mean age at diagnosis was 25.6 ± 10.8 years. The mean duration of follow-up was 14.6 ± 9.4 years, and there were 52 deaths. The cumulative survival rate was significantly lower 25 years after the diagnosis of CD (91.7%) than in the standard population model (95.7%). SMRs for both all causes [3.5; 95% confidence interval (CI): 2.7–4.6] and CD-specific causes (36.7; 95% CI 26.1–51.6) were high. Among the CD-specific causes, SMRs were especially high for small intestine and colorectal cancers, gastrointestinal diseases including intestinal failure (IF), perioperative complications, and amyloidosis. The SMRs for both all causes and CD-specific causes were high in CD patients. CD-specific causes including intestinal cancer, IF, perioperative complications, and amyloidosis showed especially high SMRs.
登录
查看更多内容
影响因子：
24.5
作者：
Hovde, Oistein;Kempski-Monstad, Iril;Moum, Bjorn A.
通讯作者：
Moum, Bjorn A.
影响因子：
4.1
作者：
Lee, Ho-Su;Choe, Jaewon;Yang, Suk-Kyun
通讯作者：
Yang, Suk-Kyun
影响因子：
1.9
作者：
Loly, Catherine;Belaiche, Jacques;Louis, Edouard
通讯作者：
Louis, Edouard
影响因子：
24.5
作者：
Masala, G;Bagnoli, S;Palli, D
通讯作者：
Palli, D
影响因子：
7.6
作者：
Canavan, C.;Abrams, K. R.;Mayberry, J. F.
通讯作者：
Mayberry, J. F.