High throughput single nanoparticle spectroscopy.

High throughput single nanoparticle spectroscopy.
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DOI:
10.1021/nn9003346
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发表时间:
2009-06-23
期刊:
影响因子:
17.1
通讯作者:
Nolan, John P.
Nolan, John P.
中科院分区:
材料科学1区
文献类型:
--
作者:
Sebba, David S.;Watson, Dakota A.;Nolan, John P.

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纳米工程系统的开发和应用进展受到定量测量技术可用性的限制。对于基于纳米颗粒(NP)的系统的工程化,单个NP表征是必不可少的,但是现有的方法缓慢且低吞吐量。我们展示了一种能够每秒分析数百个纳米粒子的流动光谱技术,并使用这种技术的纳米粒子表面增强共振拉曼散射(SERRS)标签的高通量分析。通过测量数千个单个标签的瑞利和拉曼散射,可以基于其亮度和均匀性来表征标签制备。使用高光谱分辨率流动光谱法快速分析单个纳米颗粒将在纳米工程的许多领域中有用。
Progress in the development and application of nanoengineered systems is limited by the availability of quantitative measurement techniques. For the engineering of nanoparticle (NP)-based systems, single NP characterization is essential, but existing methods are slow and low thoughput. We demonstrate a flow spectroscopy technique capable of analyzing hundreds of nanoparticles per second and use this technique for the high throughput analysis of nanoparticle surface-enhanced resonant Raman scattering (SERRS) tags. By measuring Rayleigh and Raman scattering from thousands of individual tags, tag preparations can be characterized based on their brightness and uniformity. The rapid analysis of individual nanoparticles using high spectral resolution flow spectroscopy will be useful in many areas of nanoengineering.
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