Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes.
Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes.
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产前暴露于四氯乙烯污染的饮用水和不良出生结果的风险。
DOI：
10.1289/ehp.10414
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发表时间：
2008-06
影响因子：
10.4
通讯作者：
Ozonoff, David
中科院分区：
文献类型：
--
作者：
Aschengrau, Ann;Weinberg, Janice;Rogers, Sarah;Gallagher, Lisa;Winter, Michael;Vieira, Veronica;Webster, Thomas;Ozonoff, David
关键词：
产前暴露于四氯乙烯（PCE）的先前研究显示了其对出生体重和胎龄的影响的混合结果。在这项回顾性队列研究中，我们研究了马萨诸塞州公共饮用水供应的PCE污染是否会影响母亲在分娩前暴露的儿童的出生体重和妊娠期。该研究包括1，353名母亲暴露于受PCE污染的饮用水的儿童和772名未暴露母亲的儿童。出生记录用于识别受试者并提供有关结局的信息。母亲们完成了一份问卷，以收集有关居住历史和混杂变量的信息。使用EPANET配水系统建模软件，结合归宿和运输模型，估计四氯乙烯暴露。我们没有发现PCE暴露与出生体重或妊娠期之间有意义的关联。与母亲在末次月经（LMP）年未接触的儿童相比，母亲在LMP年的平均月接触量从最低到最高四分位数不等的儿童的出生体重校正平均差异分别为20.9、6.2、30.1和15.2 g。同样，与未暴露儿童相比，母亲月平均暴露量从最低到最高四分位数的儿童的胎龄校正平均差异分别为-0.2、0.1、-0.1和-0.2周。另外两项产前接触测量也观察到类似的结果。这些结果表明，产前PCE暴露不会对这些出生结果产生不利影响，在暴露水平经历了这一人群。
Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child’s delivery. The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers’ average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were −0.2, 0.1, −0.1, and −0.2 weeks for children whose mothers’ average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population.
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影响因子：
5
作者：
BOVE, FJ;FULCOMER, MC;SAVRIN, JE
通讯作者：
SAVRIN, JE
DOI：
10.1080/00039896.1996.9936029
发表时间：
1996-07-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Aral, MM;Maslia, ML;Reyes, JJ
通讯作者：
Reyes, JJ
影响因子：
4.5
作者：
ELOVAARA, E;HEMMINKI, K;VAINIO, H
通讯作者：
VAINIO, H
影响因子：
9.8
作者：
HEALY, TEJ;POOLE, TR;HOPPER, A
通讯作者：
HOPPER, A
影响因子：
5
作者：
SAVITZ, DA;WHELAN, EA;KLECKNER, RC
通讯作者：
KLECKNER, RC