Distribution of HIV-1 and HSV-2 epidemics in Chad revealing HSV-2 hot-spot in regions of high-risk HIV spread.

Distribution of HIV-1 and HSV-2 epidemics in Chad revealing HSV-2 hot-spot in regions of high-risk HIV spread.
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DOI:
10.3855/jidc.1054
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发表时间:
2011-02-01
影响因子:
1.9
通讯作者:
Bélec L
Bélec L
中科院分区:
医学4区
文献类型:
--
作者:
Charpentier C;Koyalta D;Ndinaromtan M;Tchobkréo B;Jenabian MA;Day N;Si-Mohamed A;Weiss H;Bélec L

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单纯疱疹病毒2型(HSV-2)是人类免疫缺陷1型病毒(HIV-1)异性传播的重要辅助因子。我们有兴趣评估艾滋病毒-1和单纯疱疹病毒-2在乍得国家一级的分布情况。2007年,对HIV-1和HSV-2感染进行了一次以人群为基础的匿名血清调查,使用干血斑点。这项研究包括生活在乍得15个地区的548名成年人。标本洗脱后,进行HIV和HSV-2感染的血清学检测。全国HIV-1和HSV-2血清感染率分别为11.1%和15.7%。在单纯疱疹病毒2型感染率最高的地区,特别是在受冲突影响的达尔富尔东部两个省,艾滋病毒-1流行率与艾滋病毒-1感染率呈正相关。乍得地区需要紧急的公共卫生干预措施,在那里,单纯疱疹病毒2型的高流行率可能增加艾滋病毒传播的风险。
Herpes Simplex Virus-2 (HSV-2) is known to be a potent co-factor of Human Immunodeficiency type 1 virus (HIV-1) heterosexual transmission. We were interested in assessing the distribution of HIV-1 and HSV-2 epidemics at the national level in Chad. In 2007, a population-based anonymous serosurvey for HIV-1 and HSV-2 infections, using dried blood spots, was conducted. The study included 548 adults living in 15 regions of Chad. After specimen elution, serological testing for HIV and HSV-2 infections was performed. Countrywide, the HIV-1 and HSV-2 seroprevalences were 11.1% and 15.7%, respectively. A positive correlation was observed with the highest HIV-1 prevalence seen in regions of the highest HSV-2 prevalence, especially in two conflict-affected eastern provinces of Darfur. Urgent public health interventions are needed in regions of Chad where high HSV-2 prevalence may be increasing the risk of HIV propagation.
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