Role of the 5-HT(2A) Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin.
Role of the 5-HT(2A) Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin.
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DOI：
10.3389/fphar.2021.711255
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发表时间：
2021
影响因子：
5.6
通讯作者：
Liechti ME
中科院分区：
文献类型：
--
作者：
Holze F;Avedisian I;Varghese N;Eckert A;Liechti ME
迷幻剂麦角酰二乙胺（LSD）在研究中经历了复兴，包括评估LSD辅助心理治疗的临床试验。LSD诱导知觉改变，并以可能支持心理治疗的方式影响情绪处理。在这里，我们研究了LSD对情感共情的影响和5-羟色胺-2A（5-HT 2A）受体的介导作用，通过单独给予25、50、100和200 μ g LSD以及200 μg LSD联合5-HT 2A受体拮抗剂酮色林（40 mg）预处理，使用安慰剂对照、双盲、随机顺序、交叉设计，16名健康受试者。多方面同理心测试（MET）被用来评估LSD对情绪同理心的影响。还测量了血浆催产素水平。LSD剂量依赖性地增加了内隐和外显的情感同理心，与安慰剂相比，最高200 μg LSD剂量具有显著效果。与安慰剂相比，200 µg剂量的LSD也适度增加了血浆催产素水平。酮色林降低了LSD诱导的催产素升高，但没有降低LSD诱导的情感共情增加。这些研究结果证实，LSD增强共情，这种效果可能部分独立于其对5-HT 2A受体的主要作用，以诱导主观的迷幻效果。相反，LSD诱导的催产素释放可能依赖于5-HT 2A受体刺激，这与LSD的迷幻作用一致。需要进一步的研究来调查LSD是否也可以增强同理心，并可能对同理心缺陷和社会功能障碍的患者产生治疗效果。
The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT2A) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT2A receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT2A receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT2A receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning.
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影响因子：
3.7
作者：
Hysek CM;Simmler LD;Nicola VG;Vischer N;Donzelli M;Krähenbühl S;Grouzmann E;Huwyler J;Hoener MC;Liechti ME
通讯作者：
Liechti ME
影响因子：
64.8
作者：
Kosfeld, M;Heinrichs, M;Fehr, E
通讯作者：
Fehr, E
影响因子：
5.3
作者：
Hurlemann, Rene;Patin, Alexandra;Kendrick, Keith M.
通讯作者：
Kendrick, Keith M.
影响因子：
3.9
作者：
Dziobek, Isabel;Rogers, Kimberley;Convit, Antonio
通讯作者：
Convit, Antonio
DOI：
10.1038/s41386-020-00883-6
发表时间：
2021-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Holze F;Vizeli P;Ley L;Müller F;Dolder P;Stocker M;Duthaler U;Varghese N;Eckert A;Borgwardt S;Liechti ME
通讯作者：
Liechti ME