Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood.
Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood.
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DOI：
10.3390/nu13114176
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发表时间：
2021-11-22
期刊：
影响因子：
5.9
通讯作者：
Wühl E
中科院分区：
文献类型：
--
作者：
Drozdz D;Alvarez-Pitti J;Wójcik M;Borghi C;Gabbianelli R;Mazur A;Herceg-Čavrak V;Lopez-Valcarcel BG;Brzeziński M;Lurbe E;Wühl E
肥胖症已成为21世纪的主要流行病。它增加了患血脂异常、高血压和2型糖尿病的风险，这些都是已知的心脏代谢风险因素和代谢综合征的组成部分。尽管中风或心肌梗塞等明显的心血管疾病是成人的领域，但很明显，心血管疾病的连续体在生命的很早就开始了。在这些过程仍然可逆的时候，认识到风险因素和心血管损害的早期阶段，而制定预防战略是减少普通人群心血管发病率和死亡率的主要支柱。在这篇综述中，我们将讨论众所周知的但也是新的危险因素在肥胖和从产前到成年的心血管风险增加之间的作用，包括围产期因素、饮食、营养基因组学和营养表观遗传学、高尿酸血症、血脂异常、高血压和心肺健康的作用。强调了跟踪这些危险因素对成人简历健康的重要性，并讨论了儿童肥胖的经济影响以及预防策略。
Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also novel risk factors linking obesity and increased CV risk from prenatal age to adulthood, including the role of perinatal factors, diet, nutrigenomics, and nutri-epigenetics, hyperuricemia, dyslipidemia, hypertension, and cardiorespiratory fitness. The importance of ‘tracking’ of these risk factors on adult CV health is highlighted and the economic impact of childhood obesity as well as preventive strategies are discussed.
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DOI：
10.1111/jch.12615
发表时间：
2015-09
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
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作者：
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影响因子：
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通讯作者：
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