Targeted polymer-based antibiotic delivery system: A promising option for treating bacterial infections via macromolecular approaches
Targeted polymer-based antibiotic delivery system: A promising option for treating bacterial infections via macromolecular approaches
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基于聚合物的靶向抗生素递送系统：通过大分子方法治疗细菌感染的一个有前途的选择
DOI：
10.1016/j.progpolymsci.2021.101389
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发表时间：
2021-05
影响因子：
27.1
通讯作者：
Huang Wei
中科院分区：
文献类型：
--
作者：
Wang Tengjiao;Rong Fan;Tang Yizhang;Li Muye;Feng Tao;Zhou Qian;Li Peng;Huang Wei
抗生素治疗是治疗细菌感染的常规方法，在上个世纪已经挽救了数亿人的生命。然而，低生物利用度、副作用和耐药性细菌的出现通常与抗生素的全身给药有关。基于聚合物的抗生素给药系统（Polymer-based antibiotics delivery system，PADS）作为解决传统抗生素治疗局限性的一种方法，因其能够保护抗生素不被过早代谢并优化药代动力学而受到广泛关注。此外，PADS可以通过特异性配体-受体相互作用以主动方式或通过对内源性和外源性刺激的反应以被动方式被精心修饰以靶向感染部位。迄今为止，多种聚合物纳米结构已被用于制造PADS，例如聚合物脂质体、聚合物胶束、高度支化的聚合物和树枝状聚合物以及聚合物纳米凝胶，与相应的游离抗生素相比，其表现出增强的治疗效果。此外，还为PADS开发了整合无机或生物组分的混合纳米平台，其具有与抗生素治疗实现互补和协同作用的潜力。本文综述了近5年来PADS治疗细菌感染的研究进展，着重介绍了PADS的设计原理和靶向性，以期为今后的研究提供新的思路。
Antibiotic therapy is the routine method for treating bacterial infections and has saved hundreds of millions of lives over the last century. However, low bioavailability, side effects, and emergence of antibiotic-resistant bacteria are usually associated with the systemic administration of antibiotics. Polymer-based antibiotic delivery system (PADS), as a solution to the limitations of conventional antibiotic therapy, has received significant attention, for it is able to protect antibiotics from premature metabolism and optimize the pharmacokinetics. Moreover, PADS can be elaborately modified to target the infection sites through the specific ligand-receptor interactions in an active manner, or through the responses to endogenous and exogenous stimuli in a passive manner. Multiple polymeric nano-constructions have been used thus far to fabricate PADS, such as polymeric liposomes, polymeric micelles, highly branched polymers and dendrimers, and polymeric nanogels, exhibiting enhanced therapeutic effects compared with the corresponding free antibiotics. In addition, hybrid nanoplatforms integrating the inorganic or biological components have also been developed for PADS, which have the potential to achieve complementary and synergistic effects with antibiotic therapy. In this paper, we reviewed the advances that have been made in PADS for the treatment of bacterial infections in the past five years, highlighting the design principles and targeting capability, in an attempt to provide new insights for further researches.
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影响因子：
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影响因子：
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