Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system.
Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system.
复制标题
DOI：
10.3892/ol.2013.1231
复制
发表时间：
2013-05
期刊：
影响因子：
2.9
通讯作者：
Takenoshita S
中科院分区：
文献类型：
--
作者：
Nakamura I;Shibata M;Gonda K;Yazawa T;Shimura T;Anazawa T;Suzuki S;Sakurai K;Koyama Y;Ohto H;Tomita R;Gotoh M;Takenoshita S
据报道，血管内皮生长因子（VEGF）在恶性肿瘤的进展中具有重要作用，并且已报道诱导出现在癌症和炎症中的骨髓源性抑制细胞（MDSC）。本研究检测了消化系统肿瘤患者血清VEGF水平，并分析其与营养损害、免疫抑制及全身炎症的相关性。与健康志愿者相比，食管癌、胃癌和结直肠癌患者的VEGF血清水平显著升高。VEGF水平与血清白蛋白、前白蛋白和视黄醇结合蛋白浓度呈负相关。血清VEGF浓度与白细胞介素（IL）-12的产生呈负相关，与MDSC计数相关。VEGF水平也与中性粒细胞和中性粒细胞/淋巴细胞计数相关，与淋巴细胞计数呈负相关。血清VEGF水平以500 pg/ml的临界值划分，VEGF水平较高的患者前白蛋白和视黄醇结合蛋白水平显著降低。在VEGF水平较高的组中，刺激指数和IL-12产生显著降低，并且该组中MDSC计数倾向于较高。这些结果表明，VEGF的产生增加与全身炎症、营养障碍和涉及MDSC的细胞介导的免疫抑制相关。
Vascular endothelial growth factor (VEGF) reportedly has an important role in the progression of malignant neoplasms and has been reported to induce myeloid-derived suppressor cells (MDSCs) that appear in cancer and inflammation. In the present study, serum concentrations of VEGF were measured in patients with digestive system cancer and the correlations with nutritional damage, immune suppression and systemic inflammation were analyzed. A significant increase in VEGF serum levels was observed in patients with esophageal, gastric and colorectal cancers compared with healthy volunteers. Levels of VEGF were inversely correlated with the serum concentrations of albumin, prealbumin and retinol-binding protein. The serum concentrations of VEGF were inversely correlated with the production of interleukin (IL)-12 and correlated with MDSC counts. VEGF levels were also correlated with neutrophil and neutrophil/lymphocyte counts and inversely correlated with lymphocyte count. Serum VEGF levels were divided at a cutoff of 500 pg/ml, with levels of prealbumin and retinol-binding protein significantly decreased in patients with higher VEGF levels. The stimulation index and IL-12 production were significantly decreased in the group with higher VEGF levels and MDSC counts tended to be higher in this group. These results demonstrated that increased production of VEGF was correlated with systemic inflammation, nutritional impairment and the inhibition of cell-mediated immunity involving MDSCs.
登录
查看更多内容
影响因子：
20.3
作者：
Menetrier-Caux, C;Montmain, G;Blay, JY
通讯作者：
Blay, JY
影响因子：
5.8
作者：
Cho, HanByoul;Hur, Hye Won;Lee, Kook
通讯作者：
Lee, Kook
影响因子：
56.9
作者：
SENGER, DR;GALLI, SJ;DVORAK, HF
通讯作者：
DVORAK, HF
影响因子：
20.3
作者：
Gabrilovich, D;Ishida, T;Carbone, DP
通讯作者：
Carbone, DP
髓样衍生的抑制细胞：连接炎症和癌症。
DOI：
10.4049/jimmunol.0802740
发表时间：
2009-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ostrand-Rosenberg S;Sinha P
通讯作者：
Sinha P