The extracellular matrix in development and morphogenesis: a dynamic view.
The extracellular matrix in development and morphogenesis: a dynamic view.
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DOI：
10.1016/j.ydbio.2009.10.026
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
DeSimone, Douglas W.
中科院分区：
文献类型：
--
作者：
Rozario, Tania;DeSimone, Douglas W.
细胞外基质（ECM）由胚胎细胞在发育的最早阶段开始合成和分泌。在过去的几十年里，我们对ECM组成、结构和功能的理解有了相当大的增长，这些知识揭示了细胞外微环境对细胞生长、存活、分化和形态发生至关重要。ECM和与之相互作用的细胞受体介导与细胞骨架的物理连接以及细胞外和细胞内区室之间的双向信息流。这篇评论认为，ECM分子的细胞和组织功能的范围，并总结了最近的研究结果，具体到关键的发展过程。ECM作为生长因子的动态储存库的重要性被强调沿着最近的研究暗示ECM的三维组织和物理性质，因为它涉及细胞信号传导和形态发生细胞行为的调节。胚胎细胞和组织产生的力和ECM粘附产生的机械信号代表了该领域的新兴领域。
The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of development. Our understanding of ECM composition, structure and function has grown considerably in the last several decades and this knowledge has revealed that the extracellular microenvironment is critically important for cell growth, survival, differentiation and morphogenesis. ECM and the cellular receptors that interact with it mediate both physical linkages with the cytoskeleton and the bidirectional flow of information between the extracellular and intracellular compartments. This review considers the range of cell and tissue functions attributed to ECM molecules and summarizes recent findings specific to key developmental processes. The importance of ECM as a dynamic repository for growth factors is highlighted along with more recent studies implicating the 3-dimensional organization and physical properties of the ECM as it relates to cell signaling and the regulation of morphogenetic cell behaviors. Embryonic cell and tissue generated forces and mechanical signals arising from ECM adhesion represent emerging areas of interest in this field.
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