Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis.
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis.
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DOI：
10.3389/fncel.2015.00040
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发表时间：
2015
影响因子：
5.3
通讯作者：
Pariante CM
中科院分区：
文献类型：
--
作者：
Cattaneo A;Macchi F;Plazzotta G;Veronica B;Bocchio-Chiavetto L;Riva MA;Pariante CM
在过去的二十年中，人们越来越关注了解和表征炎症在重度抑郁症（MDD）中的作用。事实上，有几个证据将炎症系统的改变与重度抑郁症联系起来，包括促炎细胞因子水平升高以及其他炎症介质的存在。然而，目前尚不清楚炎症是否是一种原因，或者是否与抑郁症相关的其他因素导致了这些免疫学效应。无论如何，暴露于早期生活压力事件，这代表了精神疾病发展的脆弱性因素，通过炎症反应的调节起作用，而且在整个生命周期中的神经可塑性机制。事实上，早期生活中的压力事件可能会导致，可能是通过随时间持续的表观遗传变化，直到成年。这种改变可能会增加发展为精神病理学的脆弱性。在这篇综述中，我们将讨论炎症和神经元可塑性的相关过程中的作用，抑郁症的发展。此外，我们将讨论表观遗传学在诱导炎症免疫系统改变以及神经元可塑性功能障碍中的作用，从而有助于生命早期压力生活事件的长期负面影响以及随之而来的抑郁症风险增加。最后，我们将提供一个概述炎症系统的潜在作用，以帮助诊断，预测治疗反应，加强治疗匹配，并防止抑郁症的发作或复发。
During the past two decades, there has been increasing interest in understanding and characterizing the role of inflammation in major depressive disorder (MDD). Indeed, several are the evidences linking alterations in the inflammatory system to Major Depression, including the presence of elevated levels of pro-inflammatory cytokines, together with other mediators of inflammation. However, it is still not clear whether inflammation represents a cause or whether other factors related to depression result in these immunological effects. Regardless, exposure to early life stressful events, which represent a vulnerability factor for the development of psychiatric disorders, act through the modulation of inflammatory responses, but also of neuroplastic mechanisms over the entire life span. Indeed, early life stressful events can cause, possibly through epigenetic changes that persist over time, up to adulthood. Such alterations may concur to increase the vulnerability to develop psychopathologies. In this review we will discuss the role of inflammation and neuronal plasticity as relevant processes underlying depression development. Moreover, we will discuss the role of epigenetics in inducing alterations in inflammation-immune systems as well as dysfunction in neuronal plasticity, thus contributing to the long-lasting negative effects of stressful life events early in life and the consequent enhanced risk for depression. Finally we will provide an overview on the potential role of inflammatory system to aid diagnosis, predict treatment response, enhance treatment matching, and prevent the onset or relapse of Major Depression.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
1.7
作者：
Booth, Brad D.;Gulati, Sanjiv
通讯作者：
Gulati, Sanjiv
影响因子：
1.7
作者：
Basterzi, AD;Aydemir, Ç;Göka, E
通讯作者：
Göka, E
影响因子：
--
作者：
Castren, E
通讯作者：
Castren, E
影响因子：
3.4
作者：
Calabrese, Francesca;Molteni, Raffaella;Riva, Marco A.
通讯作者：
Riva, Marco A.