Retinal microvascular changes and the risk of developing obesity: population-based cohort study.
Retinal microvascular changes and the risk of developing obesity: population-based cohort study.
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DOI：
10.1111/j.1549-8719.2011.00134.x
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Klein R
中科院分区：
文献类型：
--
作者：
Shankar A;Sabanayagam C;Klein BE;Klein R
最近的研究推测，内皮和微血管功能障碍可能在肥胖的发展中发挥作用。以往的研究表明视网膜微血管改变与糖尿病、高血压和心血管疾病有关。相比之下，很少有前瞻性研究探讨视网膜微血管变化与肥胖风险之间的关系。我们检查了来自威斯康星州比弗坝人群队列的2,089名非肥胖受试者（年龄44 - 85岁，49%为女性）。从基线视网膜照片测量视网膜小动脉和小静脉直径。主要关注的结果是15年的肥胖发生率。在15年的随访期内，视网膜小静脉增宽与肥胖事件呈正相关。这种关联与年龄、性别、吸烟、饮酒、教育、体力活动、体重指数、血清胆固醇和C反应蛋白水平无关。与视网膜小静脉直径处于最低三分位数的受试者（参照）相比，处于最高三分位数的受试者中肥胖的多变量RR（95%CI）为1.68（1.24 - 2.28）; p趋势= 0.0005。相反，视网膜小动脉狭窄与肥胖无关。在一项基于人群的队列研究中，我们发现较宽的视网膜小静脉与发生肥胖的风险呈正相关，这表明微血管功能障碍在其病因学中起作用。
Recent studies have hypothesized that endothelial and microvascular dysfunction may play a role in the development of obesity. Previous studies have shown that retinal microvascular changes are associated with diabetes, hypertension, and cardiovascular disease. In contrast, few prospective studies have examined the association between retinal microvascular changes and the risk of developing obesity. We examined n=2,089 nonobese subjects from a population-based cohort in Beaver Dam, Wisconsin (aged 44-85 years, 49% women). Retinal arteriolar and venular diameters were measured from baseline retinal photographs. The main outcome-of-interest was 15-year incidence of obesity. Retinal venular widening was positively associated with incident obesity over a 15-year follow-up period. This association was independent of age, gender, smoking, alcohol intake, education, physical activity, body mass index, serum cholesterol, and C-reactive protein levels. Compared to subjects with retinal venular diameter in the lowest tertile (referent), the multivariable RR (95% CI) of obesity among subjects in the highest tertile was 1.68 (1.24-2.28); p-trend=0.0005. In contrast, narrow retinal arterioles were not associated with obesity. In a population-based cohort, we found that wider retinal venules are positively associated with risk of developing obesity, suggesting a role for microvascular dysfunction in its etiology.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
--
作者：
Liew, Gerald;Sharrett, A. Richey;Wong, Tien Y.
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Wong, Tien Y.
影响因子：
13.7
作者：
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影响因子：
6.3
作者：
Hanley, JA
通讯作者：
Hanley, JA