Information theory in vertebrate stress physiology

Information theory in vertebrate stress physiology
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脊椎动物应激生理学中的信息论

DOI:
10.1016/j.tem.2021.10.001
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发表时间:
2022
影响因子:
10.9
通讯作者:
Martin, Lynn B.
Martin, Lynn B.
中科院分区:
医学1区
文献类型:
--
作者:
Zimmer, Cedric;Woods, H. Arthur;Martin, Lynn B.

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信息论在生物学中得到了卓有成效的应用,但在内分泌学中的应用却很少。在这里,我们主张将信息论整合到应激内分泌学中。目前,大多数应激模型都集中在激素浓度的调节上,尽管内分泌学家最感兴趣的是激素的信息含量,而从个体健康和进化适应性的角度来看,这一点也很重要。在神经科学中,自由能原理是一个解释大脑如何推断环境当前和未来状态的概念,它可以指导我们解决信息是如何在激素(如糖皮质激素)中实例化的。在这里,我们提供了几个想法和有希望的选择,用于研究激素如何编码和细胞对糖皮质激素信息的反应。
Information theory has been applied productively across biology, but it has been used minimally in endocrinology. Here, we advocate for the integration of information theory into stress endocrinology. Presently, the majority of models of stress center on the regulation of hormone concentrations, even though what interests most endocrinologists and matters in terms of individual health and evolutionary fitness is the information content of hormones. In neuroscience, the free energy principle, a concept offered to explain how the brain infers current and future states of the environment, could be a guide for resolving how information is instantiated in hormones such as the glucocorticoids. Here, we offer several ideas and promising options for research addressing how hormones encode and cells respond to information in glucocorticoids.
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