Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders.
Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders.
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DOI：
10.1007/s11325-020-02047-8
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Oksenberg A
中科院分区：
文献类型：
--
作者：
Leppänen T;Kulkas A;Töyräs J;Myllymaa S;Gadoth N;Oksenberg A
高血压是阻塞性睡眠呼吸暂停（OSA）患者的常见结果，但尚不清楚高血压和血压正常的重度OSA患者之间呼吸紊乱的程度和个体呼吸事件的特征是否不同。分析了323名男性和89名女性重度OSA患者的完整多导睡眠图记录。按性别分别比较血压正常和高血压患者个体呼吸事件持续时间、总呼吸暂停和低通气时间以及呼吸紊乱占总睡眠时间的百分比（AHT%）的差异。此外，评估了三个AHT%组（AHT% ≤ 30%、30% < AHT% ≤ 45%和AHT% > 45%）之间呼吸事件特征的差异。与血压正常的女性相比，高血压女性的呼吸暂停时间百分比（15.2% vs. 18.2%，p = 0.003）和AHT%（33.5% vs. 36.5%，p = 0.021）较低。然而，在高血压和血压正常的男性之间没有观察到这些差异。与血压正常者相比，男性高血压患者的呼吸不足时间百分比更高（13.5% vs. 11.2%，p = 0.043），但女性高血压患者的呼吸不足时间百分比并不高（15.2% vs. 12.2%，p = 0.130）。AHI变异分别解释正常血压和高血压患者AHT%变异的60.5%（ρ = 0.778）和65.0%（ρ = 0.806）。然而，当AHT%增加时，AHI解释AHT%变化的能力下降。在高血压和正常血压的重度OSA患者之间，呼吸暂停和低通气时间的百分比在性别间和性别内有很大的差异。OSA是高血压的重要危险因素，因此，OSA的早期检测和表型分析将允许及时治疗高血压风险最高的患者。
Hypertension is a common finding in patients with obstructive sleep apnea (OSA), but it has remained unclear whether or not the amount of disturbed breathing and characteristics of individual respiratory events differ between hypertensive and normotensive patients with severe OSA. Full polysomnographic recordings of 323 men and 89 women with severe OSA were analyzed. Differences in the duration of individual respiratory events, total apnea and hypopnea times, and the percentage of disturbed breathing from total sleep time (AHT%) were compared between normotensive and hypertensive patients separately by genders. Furthermore, differences in the respiratory event characteristics were assessed between three AHT% groups (AHT% ≤ 30%, 30% < AHT% ≤ 45%, and AHT% > 45%). Hypertensive women had lower percentage apnea time (15.2% vs. 18.2%, p = 0.003) and AHT% (33.5% vs. 36.5%, p = 0.021) when compared with normotensive women. However, these differences were not observed between hypertensive and normotensive men. Percentage hypopnea time was higher in hypertensive men (13.5% vs. 11.2%, p = 0.043) but not in women (15.2% vs. 12.2%, p = 0.130) compared with their normotensive counterparts. The variation in AHI explained 60.5% (ρ = 0.778) and 65.0% (ρ = 0.806) of the variation in AHT% in normotensive and hypertensive patients, respectively. However, when AHT% increased, the capability of AHI to explain the variation in AHT% declined. There is a major inter- and intra-gender variation in percentage apnea and hypopnea times between hypertensive and normotensive patients with severe OSA. OSA is an important risk factor for hypertension and thus, early detection and phenotyping of OSA would allow timely treatment of patients with the highest risk of hypertension.
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影响因子：
24
作者：
Javaheri S;Barbe F;Campos-Rodriguez F;Dempsey JA;Khayat R;Javaheri S;Malhotra A;Martinez-Garcia MA;Mehra R;Pack AI;Polotsky VY;Redline S;Somers VK
通讯作者：
Somers VK
影响因子：
--
作者：
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通讯作者：
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影响因子：
7.2
作者：
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Wang W
影响因子：
24
作者：
Gami, Apoor S.;Olson, Eric J.;Shen, Win K.;Wright, R. Scott;Ballman, Karla V.;Hodge, Dave O.;Herges, Regina M.;Howard, Daniel E.;Somers, Virend K.
通讯作者：
Somers, Virend K.
影响因子：
4.3
作者：
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通讯作者：
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