Parabrachial neural coding of taste stimuli in awake rats.
Parabrachial neural coding of taste stimuli in awake rats.
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清醒大鼠味觉刺激的臂旁神经编码。
DOI：
10.1152/jn.1997.78.5.2254
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发表时间：
1997
影响因子：
2.5
通讯作者：
Norgren,R
中科院分区：
文献类型：
--
作者：
Nishijo,H;Norgren,R
[2]西条，Hisao，Ralph Norgren.清醒大鼠味觉刺激的臂旁神经编码.神经生理学杂志.78：2254-2268,1997.在清醒行为大鼠中，记录了桥臂旁核(PBN)74个神经元对15种化学物质刺激的反应。其中，44个味觉细胞接受了全部15个刺激的测试。根据它们对4种标准刺激的反应，这些神经元被分类为：23个氯化钠最佳，15个蔗糖最佳，5个柠檬酸最佳，1个奎宁盐酸盐最佳。几种形式的多变量分析表明，味觉反应既符合对SAID刺激的行为反应，也符合SAID刺激的化学结构。对神经元的分级聚类分析基本上证实了最佳刺激分类，但将氯化钠最佳细胞分为对含Na+的盐更有反应的细胞和对含氯−的盐更有反应的细胞。实际上，对Na+部分反应最好的细胞与蔗糖含量最高的细胞之间的相关性实际上要高于那些对含氯−刺激有反应的细胞。柠檬酸最好的神经元和唯一的奎宁最好的单位形成了一个单一的神经元集群，对酸、NH4Cl和较小程度的NaNO3反应良好。对神经元反应谱的因子分析表明，三个因子可以解释样本中78.8%的方差。对刺激的类似分析表明，PBN神经元对四到五组刺激做出反应，这些刺激与它们的化学组成或人类心理物理报告有关。老鼠做出这些辨别的能力已经被其他行为研究所证明，在这些研究中，啮齿动物在5种刺激类别中的每一种中概括了各种皂类化学物质。此外，对神经数据的模拟分析复制了使用Na+通道阻滞剂阿米洛利的行为结果，在该实验中，大鼠将氯化钠概括为非Na+，Cl−盐。因此，通过各种分析，在清醒的大鼠中，PBN味觉神经元的活动跟踪它们对各种化学刺激的行为反应。
Nishijo, Hisao and Ralph Norgren.Parabrachial neural coding of taste stimuli in awake rats.J. Neurophysiol.78: 2254–2268, 1997. In awake, behaving rats, the activity of 74 single neurons in the pontine parabrachial nucleus (PBN) was recorded in response to sapid stimulation by 15 chemicals. Of these, 44 taste cells were tested with all 15 stimuli. Based on their responsiveness to 4 standard stimuli, these neurons were categorized as follows: 23 NaCl-best, 15 sucrose-best, 5 citric acid–best, and 1 quinine HCl-best. Several forms of multivariate analyses indicated that the taste responses matched both the behavioral responses to and, less well, the chemical structure of, the sapid stimuli. A hierarchical cluster analysis of the neurons substantially confirmed the best-stimulus categorization, but separated the NaCl-best cells into those that responded more to Na+-containing salts and those that responded more to Cl−-containing salts. The cells that responded best to the Na+moiety actually were somewhat more correlated with the sucrose-best cells than with those that responded to the Cl−-containing stimuli. Citric acid–best neurons and the lone quinine-best unit formed a single cluster of neurons that responded well to acids, as well as to NH4Cl and, to a lesser extent, NaNO3. A factor analysis of the neuronal response profiles revealed that three factors accounted for 78.8% of the variance in the sample. Similar analyses of the stimuli suggested that PBN neurons respond to four or five sets of stimuli related by their chemical makeup or by human psychophysical reports. The capacity of rats to make these discriminations has been documented by other behavioral studies in which rodents generalize across sapid chemicals within each of 5 stimulus categories. Furthermore, a simulation analysis of the neural data replicated behavioral results that used amiloride, a Na+channel blocker, in which rats generalized NaCl to non-Na+, Cl−salts. Thus, using a variety of analyses, in awake rats, the activity of PBN taste neurons tracks their behavioral responses to a variety of chemical stimuli.
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影响因子：
2.5
作者：
D. Smith;R. L. Van Buskirk;J. Travers;S. Bieber
通讯作者：
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DOI：
--
发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1748-1716.1971.tb04988.x
发表时间：
1971
期刊：
Acta physiologica Scandinavica
影响因子：
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作者：
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通讯作者：
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