Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?
Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?
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三维染色质在感染性疾病中的基因调控和致病作用？
DOI：
10.1371/journal.ppat.1009207
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发表时间：
2021-03
期刊：
影响因子：
6.7
通讯作者：
Le Roch KG
中科院分区：
文献类型：
--
作者：
Davis SZ;Hollin T;Lenz T;Le Roch KG
最近的2019年冠状病毒病大流行再次提醒我们了解传染病的重要性。传染病研究中一个重要但未充分研究的领域是核结构或基因组在核中的物理排列在控制基因调控和致病性中的作用。研究方法的最新进展，如使用高通量测序（Hi-C）的全基因组染色体构象捕获，使得更容易分析感染性疾病病原体本身及其宿主细胞中的核结构和染色体重组。这篇综述将广泛讨论传染病中的核结构，重点是染色体重组，并简要讨论该领域下一步需要采取的步骤。在这篇综述中，我们研究了当前状态的核结构在感染性疾病的染色体重组的重点。核结构在几种病原体的转录调控以及宿主的炎症反应中起着重要作用。Hi-C等技术的最新进展使人们能够深入研究传染病发展过程中的染色体重组，并深入了解转录机制和致病性。此外，已经证明病原体也可以影响/利用宿主的核结构。这些领域在病原体中的研究严重不足，我们希望这次审查将对传染病核结构的现状进行全面审查，并为根除工作提供额外的途径。
The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field. In this review, we examine the current state of nuclear architecture in infectious diseases with an emphasis on chromosomal reorganization. Nuclear architecture plays an important role in regulation of transcription for several pathogens, as well as inflammatory responses in their host. Recent advances in technologies such as Hi-C have allowed in-depth studies of chromosomal reorganization during infectious disease development and provided insights into transcription mechanisms and pathogenicity. In addition, it has been demonstrated that pathogens can also affect/utilize the hosts nuclear architecture. These areas are heavily understudied in pathogens, and we hope this review will provide a comprehensive review on the current state of nuclear architecture in infectious diseases and provide an additional avenue for eradication efforts.
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