Connexins-Therapeutic Targets in Cancers.
Connexins-Therapeutic Targets in Cancers.
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DOI：
10.3390/ijms21239119
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发表时间：
2020-11-30
影响因子：
5.6
通讯作者：
Pawlik A
中科院分区：
文献类型：
--
作者：
Nalewajska M;Marchelek-Myśliwiec M;Opara-Bajerowicz M;Dziedziejko V;Pawlik A
连接蛋白（Cx）是形成位于间隙连接（GJ）斑块中的细胞间通道和称为半通道的单跨膜通道的蛋白质家族的成员。它们参与细胞间通讯或细胞内和细胞外环境之间的通讯。连接蛋白通过使代谢物交换或通过干扰各种信号传导途径来影响细胞稳态、生长和分化。连接蛋白的功能和表达的改变与许多疾病的发生有关。连接蛋白已经与癌症、心脏和大脑疾病、慢性肺和肾脏疾病以及伤口愈合过程有关。已显示连接蛋白抑制癌症肿瘤生长或通过促进癌细胞生长、迁移和侵袭来增加致瘤性。更好地理解与连接蛋白和细胞间通讯相关的癌症生物学的复杂性可能会导致新的治疗策略的设计。连接蛋白表达的调节可能是某些类型癌症的有效治疗方法。因此，一个重要的挑战是寻找机制和新的药物，选择性地调节各种连接蛋白亚型的表达。我们在电子数据库PubMed和EMBASE中进行了截至2020年2月的系统性文献检索。我们的检索词如下：连接蛋白，半通道，癌症和癌症治疗。本文综述了连接蛋白和间隙连接在肿瘤中的作用，并讨论了目前正在研究的可能的治疗方案。
Connexins (Cx) are members of a protein family that forms intercellular channels localised in gap junction (GJ) plaques and single transmembrane channels called hemichannels. They participate in intercellular communication or communication between the intracellular and extracellular environments. Connexins affect cell homeostasis, growth and differentiation by enabling the exchange of metabolites or by interfering with various signalling pathways. Alterations in the functionality and the expression of connexins have been linked to the occurrence of many diseases. Connexins have been already linked to cancers, cardiac and brain disorders, chronic lung and kidney conditions and wound healing processes. Connexins have been shown either to suppress cancer tumour growth or to increase tumorigenicity by promoting cancer cell growth, migration and invasiveness. A better understanding of the complexity of cancer biology related to connexins and intercellular communication could result in the design of novel therapeutic strategies. The modulation of connexin expression may be an effective therapeutic approach in some types of cancers. Therefore, one important challenge is the search for mechanisms and new drugs, selectively modulating the expression of various connexin isoforms. We performed a systematic literature search up to February 2020 in the electronic databases PubMed and EMBASE. Our search terms were as follows: connexins, hemichannels, cancer and cancer treatment. This review aims to provide information about the role of connexins and gap junctions in cancer, as well as to discuss possible therapeutic options that are currently being studied.
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影响因子：
--
作者：
Evans, W. Howard;Leybaert, Luc
通讯作者：
Leybaert, Luc
间隙连接和癌症：沟通50年。
DOI：
10.1038/nrc.2016.105
发表时间：
2016-12
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Aasen T;Mesnil M;Naus CC;Lampe PD;Laird DW
通讯作者：
Laird DW
影响因子：
6
作者：
Baklaushev, Vladimir P.;Nukolova, Natalia N.;Chekhonin, Vladimir P.
通讯作者：
Chekhonin, Vladimir P.
影响因子：
--
作者：
Alonso F;Domingos-Pereira S;Le Gal L;Derré L;Meda P;Jichlinski P;Nardelli-Haefliger D;Haefliger JA
通讯作者：
Haefliger JA
DOI：
10.1073/pnas.011417098
发表时间：
2001-01-16
影响因子：
11.1
作者：
Azzam, EI;de Toledo, SM;Little, JB
通讯作者：
Little, JB