Multifaceted roles of CCAR family proteins in the DNA damage response and cancer.
Multifaceted roles of CCAR family proteins in the DNA damage response and cancer.
复制标题
DOI：
10.1038/s12276-023-01139-1
复制
发表时间：
2024-02
影响因子：
12.8
通讯作者：
Kee, Y.
中科院分区：
文献类型：
--
作者：
Lugano, D.;Barrett, L.;Westerheide, S. D.;Kee, Y.
细胞周期凋亡调节因子（CCAR）蛋白家族由两种蛋白质CCAR1和CCAR2组成，它们在细胞生理学和病理学中发挥多种作用。这些多结构域蛋白能够进行多种相互作用和功能，在应激反应、新陈代谢和DNA损伤反应等过程中发挥作用。CCAR家族蛋白的进化保守性使其能够在秀丽隐杆线虫等模式生物中进行研究，其中揭示了CCAR在衰老中的作用。这篇综述特别强调了CCAR家族蛋白的多方面作用及其在DNA损伤反应和癌症生物学中的意义。
细胞分裂周期凋亡调节因子（CCAR，调节细胞分裂和死亡的蛋白质）在应激反应、DNA修复和寿命调节中发挥各种作用。它们的缺失或过度表达可能导致癌症，其潜在机制尚不清楚。最近的研究利用分子和细胞技术（研究细胞和分子的方法）探索了CCAR2蛋白的作用，发现人类CCAR2直接有助于DNA双链断裂的修复，突出了它在应激反应中的多种作用。研究还强调了CCAR2在DNA损伤反应和修复、凋亡、转录和衰老中的参与。这些发现可能有助于理解和治疗CCAR2基因发生改变的疾病。
本总结最初由人工智能起草，然后由作者修订和核实事实。
The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology. Cell Division Cycle Apoptosis Regulator (CCAR, proteins that regulate cell division and death) proteins play various roles in stress response, DNA repair, and longevity regulation. Their absence or overexpression could lead to cancers, with unclear underlying mechanisms. Recent studies explored the roles of CCAR2 protein, using molecular and cellular techniques (methods for studying cells and molecules), which discovered that human CCAR2 directly aids in the repair of DNA double-strand breaks, highlighting its diverse roles in stress responses. Studies also underscored the involvement of CCAR2 in the DNA damage response and repair, apoptosis, transcription, and aging. The findings could help in understanding and treating diseases that harbor alterations in CCAR2 gene. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
登录
查看更多内容
影响因子：
19
作者：
Ceccaldi R;Rondinelli B;D'Andrea AD
通讯作者：
D'Andrea AD
影响因子：
5.7
作者：
Johnson GS;Rajendran P;Dashwood RH
通讯作者：
Dashwood RH
影响因子：
28.5
作者：
Hu J;Cao J;Topatana W;Juengpanich S;Li S;Zhang B;Shen J;Cai L;Cai X;Chen M
通讯作者：
Chen M
DOI：
10.1111/febs.15732
发表时间：
2021-07
期刊：
The FEBS journal
影响因子：
--
作者：
Hnízda A;Tesina P;Nguyen TB;Kukačka Z;Kater L;Chaplin AK;Beckmann R;Ascher DB;Novák P;Blundell TL
通讯作者：
Blundell TL
影响因子：
4.2
作者：
Huan, Yongwei;Wu, Deping;Li, Guoxin
通讯作者：
Li, Guoxin