Central command increases sympathetic nerve activity during spontaneous locomotion in cats.
Central command increases sympathetic nerve activity during spontaneous locomotion in cats.
复制标题
中枢指令会增加猫自发运动期间的交感神经活动。
DOI：
10.1161/01.res.69.1.66
复制
发表时间：
1991
影响因子：
20.1
通讯作者：
Felder,RB
中科院分区：
文献类型：
--
作者：
Hajduczok,G;Hade,JS;Mark,AL;Williams,JL;Felder,RB
运动生理学中的一个有争议的问题是在运动期间交感神经活动（SNA）的调节中，中央命令与来自收缩肌肉和压力感受器的传入输入的相对贡献。最近的研究表明，行使人类的中央命令增加皮肤交感神经催汗神经活动，但挑战的概念，中央命令有助于重要的交感血管收缩神经活动增加皮肤和骨骼肌。本研究旨在探讨中枢指令对去皮质猫自发运动过程中肾脏SNA和腰部SNA的影响。在存在和不存在骨骼肌和压力感受器传入输入的情况下，研究了自发或在电刺激丘脑底运动区运动的未麻醉去皮质猫。在非瘫痪状态下的自发性节律运动与平均动脉压（MAP）从106 +/- 10至133 +/- 11 mm Hg（p <0.05）显著增加和肾SNA增加301 +/- 100%（p <0.05）相关。在麻痹猫的自发虚构节律运动期间，MAP（43 +/- 6%）、肾脏SNA（183 +/- 32%）和腰椎SNA（223 +/- 83%）也显著增加（p <0.05）。压力感受器去神经并没有减弱运动过程中MAP、肾SNA和腰SNA的增加。在麻痹猫的丘脑底运动区的电刺激期间，MAP增加了43 +/- 17%（p小于0.05），肾SNA增加了175 +/- 47%（p小于0.05）。这些发现表明，在未麻醉的去皮质猫中，中枢命令能够增加交感神经驱动。交感神经驱动的这种增加甚至在没有来自收缩肌肉或来自动脉和心肺压力感受器的反馈的情况下发生。
A controversial issue in exercise physiology is the relative contribution of central command versus afferent input from contracting muscles and baroreceptors in the regulation of sympathetic nerve activity (SNA) during exercise. Recent studies of exercising humans have suggested that central command increases cutaneous sympathetic sudomotor nerve activity but have challenged the concept that central command contributes importantly to increases in sympathetic vasoconstrictor nerve activity to skin and skeletal muscle. The purpose of this study was to examine the influence of central command on renal SNA and lumbar SNA during spontaneous locomotion in decorticate cats. Unanesthetized decorticate cats that developed locomotion spontaneously or during electrical stimulation of the subthalamic locomotor region were studied in the presence and absence of input from skeletal muscle and baroreceptor afferents. Spontaneous rhythmic locomotion in the unparalyzed state was associated with significant increases in mean arterial pressure (MAP) from 106 +/- 10 to 133 +/- 11 mm Hg (p less than 0.05) and increases in renal SNA of 301 +/- 100% (p less than 0.05). During spontaneous fictive rhythmic locomotion in paralyzed cats, there were also significant (p less than 0.05) increases in MAP (43 +/- 6%), renal SNA (183 +/- 32%), and lumbar SNA (223 +/- 83%). Baroreceptor denervation did not attenuate increases in MAP, renal SNA, and lumbar SNA during locomotion. During electrical stimulation of the subthalamic locomotor region in paralyzed cats, MAP increased by 43 +/- 17% (p less than 0.05), and renal SNA increased by 175 +/- 47% (p less than 0.05). These findings indicate that central command is capable of increasing sympathetic neural drive in unanesthetized decorticate cats. This increase in sympathetic drive occurs even in the absence of feedback from contracting muscles or from arterial and cardiopulmonary baroreceptors.
登录
查看更多内容
DOI：
10.1113/jphysiol.1913.sp001616
发表时间：
1913-10
期刊：
The Journal of Physiology
影响因子：
--
作者：
A. Krogh;J. Lindhard
通讯作者：
A. Krogh;J. Lindhard
肌肉收缩刺激下丘脑后部神经元。
DOI：
10.1152/ajpregu.1989.256.2.r348
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Waldrop,TG;Stremel,RW
通讯作者：
Stremel,RW
运动期间的心血管控制：中枢和反射神经机制。
DOI：
10.1016/0002-9149(85)91053-7
发表时间：
1985
期刊：
The American journal of cardiology
影响因子：
--
作者：
Mitchell,JH
通讯作者：
Mitchell,JH
生理学手册：第 3 节呼吸。
DOI：
--
发表时间：
1965
期刊：
影响因子：
--
作者：
W. O. Fenn;H. Rahn
通讯作者：
H. Rahn
DOI：
--
发表时间：
1971
期刊：
Journal of Physiology
影响因子：
--
作者：
By J. G. Coote;S. Hilton;J. Perez
通讯作者：
J. Perez