Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study.
Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study.
复制标题
DOI：
10.1001/archophthalmol.2009.30
复制
发表时间：
2009-05
影响因子：
--
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Baker, Michelle L.;Wang, Jie Jin;Rogers, Sophie;Klein, Ronald;Kuller, Lewis H.;Larsen, Emily K.;Wong, Tien Yin
描述老年人认知功能和痴呆与早期年龄相关性黄斑变性（AMD）的关系。一项基于人群的研究，2,088人（1769名白人和319名黑人），年龄69至97岁，参加心血管健康研究。根据改良的威斯康星州AMD分级系统，从视网膜照片评估AMD。采用数字符号替代测验（DSST）和改良简易精神状态检查（3 MSE）评估认知功能。参与者还通过详细的神经心理学测试评估了痴呆症。在控制了年龄、性别、种族和中心后，DSST评分低（最低四分位数，≤30）的人比DSST评分高的人更可能患有早期AMD（比值比[OR] 1.38; 95%置信区间[CI] 1.03，1.85）。在进一步控制教育、收缩压、总胆固醇、糖尿病、吸烟状况和APOE基因型的分析中，这种关联更强（OR 2.00; 95%CI，1.29，3.10）。与低3 MSE评分、痴呆或阿尔茨海默病与早期AMD无关。在老年人群中，认知功能障碍可能与早期AMD具有共同的年龄相关病理生理学和风险因素。
To describe the association of cognitive function and dementia with early age-related macular degeneration (AMD) in older individuals. A population-based study of 2,088 persons (1769 whites and 319 blacks) aged 69 to 97 years participating in the Cardiovascular Health Study. AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST) and the Modified Mini-Mental State Examination (3MSE). Participants were also evaluated for dementia with detailed neuropsychological testing. After controlling for age, gender, race, and center, persons with low DSST scores (lowest quartile of scores, ≤30) were more likely to have early AMD (odds ratio [OR] 1.38; 95% confidence intervals [CI] 1.03, 1.85) than persons with higher DSST scores. In analyses further controlling for education, systolic blood pressure, total cholesterol, diabetes, smoking status and APOE genotype, this association was stronger (OR 2.00; 95% CI, 1.29, 3.10). There was no association with low 3MSE scores, dementia or Alzheimer’s disease with early AMD. In this older population, cognitive impairment may share common age-related pathophysiology and risk factors with early AMD.
登录
查看更多内容
影响因子：
2.8
作者：
FURBERG, CD;MANOLIO, TA;RAUTAHARJU, PM
通讯作者：
RAUTAHARJU, PM
影响因子：
120.7
作者：
Evans, DA;Beckett, LA;Mayeux, R
通讯作者：
Mayeux, R
影响因子：
5.7
作者：
Lopez, OL;Kuller, LH;Beauchamp, N
通讯作者：
Beauchamp, N
DOI：
10.1097/00005072-199712000-00001
发表时间：
1997-12-01
影响因子：
3.2
作者：
Mrak, RE;Griffin, WST;Graham, DI
通讯作者：
Graham, DI
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM