Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults.
Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults.
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DOI：
10.1007/s00125-011-2268-4
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发表时间：
2012-01
期刊：
影响因子：
8.2
通讯作者：
Hu, F. B.
中科院分区：
文献类型：
--
作者：
Pan, A.;Sun, Q.;Okereke, O. I.;Rexrode, K. M.;Rubin, R. R.;Lucas, M.;Willett, W. C.;Manson, J. E.;Hu, F. B.
几项研究表明，抗抑郁药物（ADM）的使用和2型糖尿病之间存在潜在的正相关。我们在三组美国成年人中研究了这种关联。我们在卫生专业人员随访研究（HPFS，1990-2006）中跟踪了29，776名男性，在护士健康研究I（NHS I，1996-2008）中跟踪了61，791名女性，在NHS II（1993-2005）中跟踪了76，868名女性，这些人在基线时没有糖尿病、心血管疾病或癌症。HPFS、NHS I和II的平均基线年龄分别为56.4岁、61.3岁和38.1岁。在基线时评估ADM使用和其他协变量，并每2年更新一次。使用时间依赖性考克斯比例风险模型，并将三个队列的HR汇总在一起。在1，644，679人年的随访中，我们记录了6，641例2型糖尿病新发病例。在年龄校正模型中，ADM使用与所有三个队列中糖尿病风险增加相关（合并HR 1.68 [95% CI 1.27，2.23]）。在调整糖尿病风险因素和高胆固醇和高血压史后，相关性减弱（1.30; 1.14，1.49），并通过控制更新的BMI进一步减弱（1.17; 1.09，1.25）。使用选择性5-羟色胺再摄取抑制剂和其他抗抑郁药（主要是三环类抗抑郁药）均与糖尿病风险升高相关，合并多变量校正的HR分别为1.10（1.00，1.22）和1.26（1.11，1.42）。结果表明，ADM使用者与非使用者相比，即使在调整BMI后，2型糖尿病的风险也适度升高。
Several studies suggested a potential positive association between antidepressant medication (ADM) use and incident type 2 diabetes mellitus. We examined this association in three cohorts of US adults. We followed 29,776 men in the Health Professionals Follow-up Study (HPFS, 1990–2006), 61,791 women in the Nurses’ Health Study I (NHS I, 1996–2008) and 76,868 women in NHS II (1993–2005), who were free of diabetes mellitus, cardiovascular disease, or cancer at baseline. The mean baseline ages for HPFS, NHS I and II were 56.4, 61.3 and 38.1 years old, respectively. ADM use and other covariates were assessed at baseline and updated every 2 years. Time-dependent Cox proportional hazards model was used, and HRs were pooled together across the three cohorts. During 1,644,679 person-years of follow-up, we documented 6,641 new cases of type 2 diabetes. ADM use was associated with an increased risk of diabetes in all three cohorts in age-adjusted models (pooled HR 1.68 [95% CI 1.27, 2.23]). The association was attenuated after adjustment for diabetes risk factors and histories of high cholesterol and hypertension (1.30; 1.14, 1.49), and further attenuated by controlling for updated BMI (1.17; 1.09, 1.25). Uses of selective serotonin reuptake inhibitors and other antidepressants (mainly tricyclic antidepressants) were both associated with an elevated risk of diabetes, with pooled multivariate-adjusted HRs of 1.10 (1.00, 1.22) and 1.26 (1.11, 1.42), respectively. The results suggest that ADM users had a moderately elevated risk of type 2 diabetes mellitus compared to non-users, even after adjustment for BMI.
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影响因子：
16.2
作者：
Rubin RR;Ma Y;Peyrot M;Marrero DG;Price DW;Barrett-Connor E;Knowler WC;Diabetes Prevention Program Research Group
通讯作者：
Diabetes Prevention Program Research Group
影响因子：
158.5
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通讯作者：
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作者：
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