Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012.
Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012.
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DOI：
10.1093/infdis/jiv351
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发表时间：
2015-10-01
期刊：
影响因子：
--
通讯作者：
Rollin PE
中科院分区：
文献类型：
--
作者：
Knust B;Schafer IJ;Wamala J;Nyakarahuka L;Okot C;Shoemaker T;Dodd K;Gibbons A;Balinandi S;Tumusiime A;Campbell S;Newman E;Lasry E;DeClerck H;Boum Y;Makumbi I;Bosa HK;Mbonye A;Aceng JR;Nichol ST;Ströher U;Rollin PE
2012年10月，乌干达报告了一系列疾病和死亡，经确认是马尔堡病毒病爆发。使用标准调查表对符合病例标准的患者进行访谈，并通过逆转录-聚合酶链反应（RT-PCR）和抗体酶联免疫吸附试验检测血液标本是否存在急性或近期马尔堡病毒感染的证据。确诊和可能MVD病例总数为26例，其中15例（58%）为致死性。15例实验室确诊病例中有4例（27%）是致命的。病例患者分布在乌干达的4个不同地区，但所有传播链都起源于伊班达地区，最早发现的病例是在2012年7月发病的。未发现人畜共患病暴露。与MVD病例显著相关的症状包括打嗝、厌食、疲劳、呕吐、咽喉痛和吞咽困难。与病例患者接触和参加葬礼也与病例显著相关。急性期致死性病例的平均RT-PCR循环阈值显著低于非致死性病例。在采取接触者追踪、积极病例监测、采取隔离预防措施护理患者、社区动员和快速诊断检测等措施后，疫情在首次发现后14天被成功控制。
In October 2012, a cluster of illnesses and deaths was reported in Uganda and was confirmed to be an outbreak of Marburg virus disease (MVD). Patients meeting the case criteria were interviewed using a standard investigation form, and blood specimens were tested for evidence of acute or recent Marburg virus infection by reverse transcription–polymerase chain reaction (RT-PCR) and antibody enzyme-linked immunosorbent assay. The total count of confirmed and probable MVD cases was 26, of which 15 (58%) were fatal. Four of 15 laboratory-confirmed cases (27%) were fatal. Case patients were located in 4 different districts in Uganda, although all chains of transmission originated in Ibanda District, and the earliest case detected had an onset in July 2012. No zoonotic exposures were identified. Symptoms significantly associated with being a MVD case included hiccups, anorexia, fatigue, vomiting, sore throat, and difficulty swallowing. Contact with a case patient and attending a funeral were also significantly associated with being a case. Average RT-PCR cycle threshold values for fatal cases during the acute phase of illness were significantly lower than those for nonfatal cases. Following the institution of contact tracing, active case surveillance, care of patients with isolation precautions, community mobilization, and rapid diagnostic testing, the outbreak was successfully contained 14 days after its initial detection.
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影响因子：
3.7
作者：
Albarino, C. G.;Shoemaker, T.;Stroeher, U.
通讯作者：
Stroeher, U.
影响因子：
5.4
作者：
Towner, JS;Rollin, PE;Nichol, ST
通讯作者：
Nichol, ST
影响因子：
6.4
作者：
Ksiazek, TG;West, CP;Peters, CJ
通讯作者：
Peters, CJ
影响因子：
6.4
作者：
Kortepeter, Mark G.;Bausch, Daniel G.;Bray, Mike
通讯作者：
Bray, Mike
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y