Circadian control of human cardiovascular function.

Circadian control of human cardiovascular function.
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DOI:
10.1016/j.coph.2021.01.002
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发表时间:
2021-04
影响因子:
4
通讯作者:
Shea SA
Shea SA
中科院分区:
医学3区
文献类型:
--
作者:
Thosar SS;Shea SA

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内源性昼夜节律为心血管(CV)系统的最佳功能做好准备,以匹配日常预期的行为和环境周期,包括白天醒来时的各种活动和晚上睡觉时的休养。大多数CV变量的整体昼夜模式是可预测的昼夜节律效应与对CV系统的不同行为和环境影响的总和。昼夜节律系统也与早高峰不良心血管事件的发生率有关,包括心肌梗死、中风和心脏性猝死。我们讨论了人类心血管生理的休息和应激反应昼夜节律控制,并提出了未来的研究机会,包括通过相对于人体内部生物钟时间的最佳时机治疗来改进心血管治疗。
Endogenous circadian rhythms prepare the cardiovascular (CV) system for optimal function to match the daily anticipated behavioral and environmental cycles, including variable activities when awake during the day and recuperation when sleeping at night. The overall day-night patterns in most CV variables result from the summation of predictable circadian effects with variable behavioral and environmental effects on the CV system. The circadian system has also been implicated in the morning peak in the incidence of adverse CV events, including myocardial infarction, stroke, and sudden cardiac death. We discuss the resting and stress-reactive circadian control of CV physiology in humans and suggest future research opportunities, including improving CV therapy by optimally timing therapy relative to a person’s internal body clock time.
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